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Acyl-CoA Thioesterase 1 (ACOT1) Regulates PPARα to Couple Fatty Acid Flux With Oxidative Capacity During Fasting

Hepatic acyl-CoA thioesterase 1 (ACOT1) catalyzes the conversion of acyl-CoAs to fatty acids (FAs) and CoA. We sought to determine the role of ACOT1 in hepatic lipid metabolism in C57Bl/6J male mice 1 week after adenovirus-mediated Acot1 knockdown. Acot1 knockdown reduced liver triglyceride (TG) as...

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Detalles Bibliográficos
Autores principales:	Franklin, Mallory P., Sathyanarayan, Aishwarya, Mashek, Douglas G.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	American Diabetes Association 2017
Materias:	Metabolism
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5521868/ https://www.ncbi.nlm.nih.gov/pubmed/28607105 http://dx.doi.org/10.2337/db16-1519

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