Durable Local Control Following Concurrent Hypofractionated Chemoradiation for a Massive Inflammatory Breast Cancer Chest Wall Recurrence

Breast cancer is the leading new cancer diagnosis in women in the United States and is the second most lethal cancer in this patient population after lung cancer. Chest wall recurrence after mastectomy poses unique clinical challenges, as such tumors are often not amenable to surgical resection and durable local control with radiation or systemic therapy is challenging. When uncontrolled, chest wall recurrence can lead to severe pain and other morbidity. Herein, we describe a patient with inflammatory breast cancer with a massive, rapidly growing chest wall recurrence treated with a regimen of hypofractionated concurrent chemoradiation resulting in a complete chest wall response with durable local control.