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Oncogenic STAT5 signaling promotes oxidative stress in chronic myeloid leukemia cells by repressing antioxidant defenses

STAT5 transcription factors are frequently activated in hematopoietic neoplasms and are targets of various tyrosine kinase oncogenes. Evidences for a crosstalk between STAT5 and reactive oxygen species (ROS) metabolism have recently emerged but mechanisms involved in STAT5-mediated regulation of ROS...

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Detalles Bibliográficos
Autores principales:	Bourgeais, Jerome, Ishac, Nicole, Medrzycki, Magdalena, Brachet-Botineau, Marie, Desbourdes, Laura, Gouilleux-Gruart, Valerie, Pecnard, Emmanuel, Rouleux-Bonnin, Florence, Gyan, Emmanuel, Domenech, Jorge, Mazurier, Frederic, Moriggl, Richard, Bunting, Kevin D., Herault, Olivier, Gouilleux, Fabrice
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2016
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522035/ https://www.ncbi.nlm.nih.gov/pubmed/27566554 http://dx.doi.org/10.18632/oncotarget.11480

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