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LncRNAs as an intermediate in HPV16 promoting myeloid-derived suppressor cell recruitment of head and neck squamous cell carcinoma

The emerging evidence showed that long noncoding RNAs (lncRNAs) are involved in cell growth and apoptosis as well as cancer progression and metastasis of malignant tumor, however, limited data are available on the role of lncRNAs in human papillomavirus (HPV)-associated Head and neck squamous cell c...

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Autores principales: Ma, Xiangrui, Sheng, Surui, Wu, Jingbiao, Jiang, Yaping, Gao, Xiaolei, Cen, Xiao, Wu, Jiashun, Wang, Shasha, Tang, Yajie, Tang, Yaling, Liang, Xinhua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522049/
https://www.ncbi.nlm.nih.gov/pubmed/28159935
http://dx.doi.org/10.18632/oncotarget.14939
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author Ma, Xiangrui
Sheng, Surui
Wu, Jingbiao
Jiang, Yaping
Gao, Xiaolei
Cen, Xiao
Wu, Jiashun
Wang, Shasha
Tang, Yajie
Tang, Yaling
Liang, Xinhua
author_facet Ma, Xiangrui
Sheng, Surui
Wu, Jingbiao
Jiang, Yaping
Gao, Xiaolei
Cen, Xiao
Wu, Jiashun
Wang, Shasha
Tang, Yajie
Tang, Yaling
Liang, Xinhua
author_sort Ma, Xiangrui
collection PubMed
description The emerging evidence showed that long noncoding RNAs (lncRNAs) are involved in cell growth and apoptosis as well as cancer progression and metastasis of malignant tumor, however, limited data are available on the role of lncRNAs in human papillomavirus (HPV)-associated Head and neck squamous cell carcinomas (HNSCC). Here, we demonstrated that 23.98% of 196 HNSCC cases in Southwest China could be classified as HPV16 infection. The number of MDSCs in HPV-positive HNSCC was significantly higher than normal control, indicating that HPV infection may promote MDSCs aggregation. Then, we applied an array-based approach to monitor the lncRNA expression between HPV-positive HNSCC, HPV-negative HNSCC and normal oral mucous, and obtained 132 different lncRNAs in different HPV infected states of HNSCC. HOTAIR, PROM1, CCAT1, and MUC19 mRNA levels, determined by qRT-PCR were inversely correlated with MDSCs collection of HPV-associated HNSCC in 2 independent patient cohorts. The results may provide a rationale for the further evaluation of lncRNAs as a molecular target to elucidate the molecular mechanism of HPV promoting MDSCs collection of HNSCC.
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spelling pubmed-55220492017-08-08 LncRNAs as an intermediate in HPV16 promoting myeloid-derived suppressor cell recruitment of head and neck squamous cell carcinoma Ma, Xiangrui Sheng, Surui Wu, Jingbiao Jiang, Yaping Gao, Xiaolei Cen, Xiao Wu, Jiashun Wang, Shasha Tang, Yajie Tang, Yaling Liang, Xinhua Oncotarget Research Paper The emerging evidence showed that long noncoding RNAs (lncRNAs) are involved in cell growth and apoptosis as well as cancer progression and metastasis of malignant tumor, however, limited data are available on the role of lncRNAs in human papillomavirus (HPV)-associated Head and neck squamous cell carcinomas (HNSCC). Here, we demonstrated that 23.98% of 196 HNSCC cases in Southwest China could be classified as HPV16 infection. The number of MDSCs in HPV-positive HNSCC was significantly higher than normal control, indicating that HPV infection may promote MDSCs aggregation. Then, we applied an array-based approach to monitor the lncRNA expression between HPV-positive HNSCC, HPV-negative HNSCC and normal oral mucous, and obtained 132 different lncRNAs in different HPV infected states of HNSCC. HOTAIR, PROM1, CCAT1, and MUC19 mRNA levels, determined by qRT-PCR were inversely correlated with MDSCs collection of HPV-associated HNSCC in 2 independent patient cohorts. The results may provide a rationale for the further evaluation of lncRNAs as a molecular target to elucidate the molecular mechanism of HPV promoting MDSCs collection of HNSCC. Impact Journals LLC 2017-02-01 /pmc/articles/PMC5522049/ /pubmed/28159935 http://dx.doi.org/10.18632/oncotarget.14939 Text en Copyright: © 2017 Ma et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Ma, Xiangrui
Sheng, Surui
Wu, Jingbiao
Jiang, Yaping
Gao, Xiaolei
Cen, Xiao
Wu, Jiashun
Wang, Shasha
Tang, Yajie
Tang, Yaling
Liang, Xinhua
LncRNAs as an intermediate in HPV16 promoting myeloid-derived suppressor cell recruitment of head and neck squamous cell carcinoma
title LncRNAs as an intermediate in HPV16 promoting myeloid-derived suppressor cell recruitment of head and neck squamous cell carcinoma
title_full LncRNAs as an intermediate in HPV16 promoting myeloid-derived suppressor cell recruitment of head and neck squamous cell carcinoma
title_fullStr LncRNAs as an intermediate in HPV16 promoting myeloid-derived suppressor cell recruitment of head and neck squamous cell carcinoma
title_full_unstemmed LncRNAs as an intermediate in HPV16 promoting myeloid-derived suppressor cell recruitment of head and neck squamous cell carcinoma
title_short LncRNAs as an intermediate in HPV16 promoting myeloid-derived suppressor cell recruitment of head and neck squamous cell carcinoma
title_sort lncrnas as an intermediate in hpv16 promoting myeloid-derived suppressor cell recruitment of head and neck squamous cell carcinoma
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522049/
https://www.ncbi.nlm.nih.gov/pubmed/28159935
http://dx.doi.org/10.18632/oncotarget.14939
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