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Long non-coding RNA-CRNDE: a novel regulator of tumor growth and angiogenesis in hepatoblastoma
Long non-coding RNAs (lncRNAs) are involved in many biological processes, such as angiogenesis, invasion, cell proliferation, and apoptosis. They have emerged as key players in the pathology of several tumors, including hepatoblastoma. In this study, we elucidate the biological and clinical signific...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Impact Journals LLC
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522051/ https://www.ncbi.nlm.nih.gov/pubmed/28178668 http://dx.doi.org/10.18632/oncotarget.14992 |
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author | Dong, Rui Liu, Xiang-Qi Zhang, Bin-Bin Liu, Bai-Hui Zheng, Shan Dong, Kui-Ran |
author_facet | Dong, Rui Liu, Xiang-Qi Zhang, Bin-Bin Liu, Bai-Hui Zheng, Shan Dong, Kui-Ran |
author_sort | Dong, Rui |
collection | PubMed |
description | Long non-coding RNAs (lncRNAs) are involved in many biological processes, such as angiogenesis, invasion, cell proliferation, and apoptosis. They have emerged as key players in the pathology of several tumors, including hepatoblastoma. In this study, we elucidate the biological and clinical significance of CRNDE up-regulation in hepatoblastoma. CRNDE is significantly up-regulated in human hepatoblastoma specimens and metastatic hepatoblastoma cell lines. CRNDE knockdown reduces tumor growth and tumor angiogenesis in vivo, and decreases hepatoblastoma cell viability, proliferation, and angiogenic effect in vitro. Mechanistic studies show that CRNDE knockdown plays its anti-proliferation and anti-angiogenesis role via regulating mammalian target of rapamycin (mTOR) signaling. Taken together, this study reveals a crucial role of CRNDE in the pathology of hepatoblastoma. CRNDE may serve as a promising diagnostic marker and therapeutic target for hepatoblastoma. |
format | Online Article Text |
id | pubmed-5522051 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Impact Journals LLC |
record_format | MEDLINE/PubMed |
spelling | pubmed-55220512017-08-08 Long non-coding RNA-CRNDE: a novel regulator of tumor growth and angiogenesis in hepatoblastoma Dong, Rui Liu, Xiang-Qi Zhang, Bin-Bin Liu, Bai-Hui Zheng, Shan Dong, Kui-Ran Oncotarget Research Paper Long non-coding RNAs (lncRNAs) are involved in many biological processes, such as angiogenesis, invasion, cell proliferation, and apoptosis. They have emerged as key players in the pathology of several tumors, including hepatoblastoma. In this study, we elucidate the biological and clinical significance of CRNDE up-regulation in hepatoblastoma. CRNDE is significantly up-regulated in human hepatoblastoma specimens and metastatic hepatoblastoma cell lines. CRNDE knockdown reduces tumor growth and tumor angiogenesis in vivo, and decreases hepatoblastoma cell viability, proliferation, and angiogenic effect in vitro. Mechanistic studies show that CRNDE knockdown plays its anti-proliferation and anti-angiogenesis role via regulating mammalian target of rapamycin (mTOR) signaling. Taken together, this study reveals a crucial role of CRNDE in the pathology of hepatoblastoma. CRNDE may serve as a promising diagnostic marker and therapeutic target for hepatoblastoma. Impact Journals LLC 2017-02-02 /pmc/articles/PMC5522051/ /pubmed/28178668 http://dx.doi.org/10.18632/oncotarget.14992 Text en Copyright: © 2017 Dong et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited. |
spellingShingle | Research Paper Dong, Rui Liu, Xiang-Qi Zhang, Bin-Bin Liu, Bai-Hui Zheng, Shan Dong, Kui-Ran Long non-coding RNA-CRNDE: a novel regulator of tumor growth and angiogenesis in hepatoblastoma |
title | Long non-coding RNA-CRNDE: a novel regulator of tumor growth and angiogenesis in hepatoblastoma |
title_full | Long non-coding RNA-CRNDE: a novel regulator of tumor growth and angiogenesis in hepatoblastoma |
title_fullStr | Long non-coding RNA-CRNDE: a novel regulator of tumor growth and angiogenesis in hepatoblastoma |
title_full_unstemmed | Long non-coding RNA-CRNDE: a novel regulator of tumor growth and angiogenesis in hepatoblastoma |
title_short | Long non-coding RNA-CRNDE: a novel regulator of tumor growth and angiogenesis in hepatoblastoma |
title_sort | long non-coding rna-crnde: a novel regulator of tumor growth and angiogenesis in hepatoblastoma |
topic | Research Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522051/ https://www.ncbi.nlm.nih.gov/pubmed/28178668 http://dx.doi.org/10.18632/oncotarget.14992 |
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