Beluga whale pVHL enhances HIF-2α activity via inducing HIF-2α proteasomal degradation under hypoxia

Aquatic mammals, such as cetaceans experience various depths, with accordingly diverse oxygenation, thus, cetaceans have developed adaptations for hypoxia, but mechanisms underlying this tolerance to low oxygen are unclear. Here we analyzed VHL and HIF-2α, in the hypoxia signaling pathway. Variation...

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Detalles Bibliográficos
Autores principales: Bi, Jianling, Hu, Bo, Wang, Jing, Liu, Xing, Zheng, Jinsong, Wang, Ding, Xiao, Wuhan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522066/
https://www.ncbi.nlm.nih.gov/pubmed/28178687
http://dx.doi.org/10.18632/oncotarget.15038

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522066/
https://www.ncbi.nlm.nih.gov/pubmed/28178687
http://dx.doi.org/10.18632/oncotarget.15038

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