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Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study

OBJECTIVES: Serum uric acid has been suggested to be associated with cancer risk. We aimed to study the association between serum uric acid and cancer incidence in a large Swedish cohort. RESULTS: A positive association was found between uric acid levels and overall cancer risk, and results were sim...

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Autores principales: Yiu, Andrew, Van Hemelrijck, Mieke, Garmo, Hans, Holmberg, Lars, Malmström, Håkan, Lambe, Mats, Hammar, Niklas, Walldius, Göran, Jungner, Ingmar, Wulaningsih, Wahyu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522070/
https://www.ncbi.nlm.nih.gov/pubmed/28418841
http://dx.doi.org/10.18632/oncotarget.16198
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author Yiu, Andrew
Van Hemelrijck, Mieke
Garmo, Hans
Holmberg, Lars
Malmström, Håkan
Lambe, Mats
Hammar, Niklas
Walldius, Göran
Jungner, Ingmar
Wulaningsih, Wahyu
author_facet Yiu, Andrew
Van Hemelrijck, Mieke
Garmo, Hans
Holmberg, Lars
Malmström, Håkan
Lambe, Mats
Hammar, Niklas
Walldius, Göran
Jungner, Ingmar
Wulaningsih, Wahyu
author_sort Yiu, Andrew
collection PubMed
description OBJECTIVES: Serum uric acid has been suggested to be associated with cancer risk. We aimed to study the association between serum uric acid and cancer incidence in a large Swedish cohort. RESULTS: A positive association was found between uric acid levels and overall cancer risk, and results were similar with adjustment for glucose, triglycerides and BMI. Hazard ratio (HR) for overall cancer for the 4(th) quartile of uric acid compared to the 1(st) was 1.08 (95% CI: 1.05–1.11) in men and 1.12 (1.09 – 1.16) in women. Site-specific analysis showed a positive association between uric acid and risk of colorectal, hepatobiliary, kidney, non-melanoma skin, and other cancers in men and of head and neck and other cancers in women. An inverse association was observed for pulmonary and central nervous system (CNS) cancers in men and breast, lymphatic and haematological, and CNS malignancies in women. MATERIALS AND METHODS: We included 493,281 persons aged 20 years and older who had a measurement of serum uric acid and were cancer-free at baseline in the AMORIS study. Multivariable Cox proportional hazards regression was used to investigate sex-specific quartiles of serum uric acid in relation to cancer risk in men and women. Analysis was further adjusted for serum glucose, triglycerides and, where available, BMI. Site-specific analysis was performed for major cancers. CONCLUSIONS: Altered uric acid levels were associated with risk of overall and some specific cancers, further indicating the potential role of uric acid metabolism in carcinogenesis.
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spelling pubmed-55220702017-08-08 Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study Yiu, Andrew Van Hemelrijck, Mieke Garmo, Hans Holmberg, Lars Malmström, Håkan Lambe, Mats Hammar, Niklas Walldius, Göran Jungner, Ingmar Wulaningsih, Wahyu Oncotarget Research Paper OBJECTIVES: Serum uric acid has been suggested to be associated with cancer risk. We aimed to study the association between serum uric acid and cancer incidence in a large Swedish cohort. RESULTS: A positive association was found between uric acid levels and overall cancer risk, and results were similar with adjustment for glucose, triglycerides and BMI. Hazard ratio (HR) for overall cancer for the 4(th) quartile of uric acid compared to the 1(st) was 1.08 (95% CI: 1.05–1.11) in men and 1.12 (1.09 – 1.16) in women. Site-specific analysis showed a positive association between uric acid and risk of colorectal, hepatobiliary, kidney, non-melanoma skin, and other cancers in men and of head and neck and other cancers in women. An inverse association was observed for pulmonary and central nervous system (CNS) cancers in men and breast, lymphatic and haematological, and CNS malignancies in women. MATERIALS AND METHODS: We included 493,281 persons aged 20 years and older who had a measurement of serum uric acid and were cancer-free at baseline in the AMORIS study. Multivariable Cox proportional hazards regression was used to investigate sex-specific quartiles of serum uric acid in relation to cancer risk in men and women. Analysis was further adjusted for serum glucose, triglycerides and, where available, BMI. Site-specific analysis was performed for major cancers. CONCLUSIONS: Altered uric acid levels were associated with risk of overall and some specific cancers, further indicating the potential role of uric acid metabolism in carcinogenesis. Impact Journals LLC 2017-03-15 /pmc/articles/PMC5522070/ /pubmed/28418841 http://dx.doi.org/10.18632/oncotarget.16198 Text en Copyright: © 2017 Yiu et al. http://creativecommons.org/licenses/by/3.0/ This article is distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/3.0/) (CC-BY), which permits unrestricted use and redistribution provided that the original author and source are credited.
spellingShingle Research Paper
Yiu, Andrew
Van Hemelrijck, Mieke
Garmo, Hans
Holmberg, Lars
Malmström, Håkan
Lambe, Mats
Hammar, Niklas
Walldius, Göran
Jungner, Ingmar
Wulaningsih, Wahyu
Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study
title Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study
title_full Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study
title_fullStr Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study
title_full_unstemmed Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study
title_short Circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the AMORIS Study
title_sort circulating uric acid levels and subsequent development of cancer in 493,281 individuals: findings from the amoris study
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522070/
https://www.ncbi.nlm.nih.gov/pubmed/28418841
http://dx.doi.org/10.18632/oncotarget.16198
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