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Type Iγ phosphatidylinositol phosphate kinase regulates PD-L1 expression by activating NF-κB

The programmed death-ligand 1 (PD-L1), by binding to PD-1 on the surface of immune cells, activates a major immune checkpoint pathway. Elevated expression of PD-L1 in tumor cells mediates tumor-induced T-cell exhaustion and immune suppression; therefore protect the survival of tumor cells. Although...

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Detalles Bibliográficos
Autores principales:	Xue, Junli, Chen, Chunhua, Qi, Manlong, Huang, Yan, Wang, Lin, Gao, Yong, Dong, Haidong, Ling, Kun
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522076/ https://www.ncbi.nlm.nih.gov/pubmed/28465490 http://dx.doi.org/10.18632/oncotarget.17123

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