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Discovery and characterization of small molecules targeting the DNA-binding ETS domain of ERG in prostate cancer

Genomic alterations involving translocations of the ETS-related gene ERG occur in approximately half of prostate cancer cases. These alterations result in aberrant, androgen-regulated production of ERG protein variants that directly contribute to disease development and progression. This study descr...

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Detalles Bibliográficos
Autores principales:	Butler, Miriam S., Roshan-Moniri, Mani, Hsing, Michael, Lau, Desmond, Kim, Ari, Yen, Paul, Mroczek, Marta, Nouri, Mannan, Lien, Scott, Axerio-Cilies, Peter, Dalal, Kush, Yau, Clement, Ghaidi, Fariba, Guo, Yubin, Yamazaki, Takeshi, Lawn, Sam, Gleave, Martin E., Gregory-Evans, Cheryl Y., McIntosh, Lawrence P., Cox, Michael E., Rennie, Paul S., Cherkasov, Artem
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522078/ https://www.ncbi.nlm.nih.gov/pubmed/28465491 http://dx.doi.org/10.18632/oncotarget.17124

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