Restoration of p53 using the novel MDM2-p53 antagonist APG115 suppresses dedifferentiated papillary thyroid cancer cells

Dedifferentiated papillary thyroid cancer (DePTC) is characterized by aggressive growth, recurrence, distant metastasis, and resistance to radioactive iodine (RAI) therapy. DePTC is also accompanied by poor prognosis and high early-mortality. Nevertheless, most DePTC cells show intact p53 downstream...

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Detalles Bibliográficos
Autores principales: Chen, Haibo, Luo, Dingyuan, Zhang, Lin, Lin, Xiaofeng, Luo, Qiuyun, Yi, Hanjie, Wang, Jing, Yan, Xianglei, Li, Baoxia, Chen, Yuelei, Liu, Xingguang, Zhang, Hong, Liu, Sheng, Qiu, Miaozhen, Yang, Dajun, Jiang, Ningyi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522123/
https://www.ncbi.nlm.nih.gov/pubmed/28498808
http://dx.doi.org/10.18632/oncotarget.17398

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