An anti-cancer WxxxE-containing azurin polypeptide inhibits Rac1-dependent STAT3 and ERK/GSK-3β signaling in breast cancer cells

In our previous study, we characterized a mycoplasmal small GTPase-like polypeptide of 240 amino acids that possesses an N-terminal WVLGE sequence. The N-terminal WVLGE sequence promotes activation of Rac1 and subsequent host cancer cell proliferation. To investigate the function of the WxxxE motif...

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Detalles Bibliográficos
Autores principales: Zhang, Zhe, Luo, Zhiyong, Min, Wenpu, Zhang, Lin, Wu, Yaqun, Hu, Xiaopeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522130/
https://www.ncbi.nlm.nih.gov/pubmed/28549350
http://dx.doi.org/10.18632/oncotarget.17759

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522130/
https://www.ncbi.nlm.nih.gov/pubmed/28549350
http://dx.doi.org/10.18632/oncotarget.17759

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