Indoleamine 2,3-dioxygenase 1 deficiency attenuates CCl(4)-induced fibrosis through Th17 cells down-regulation and tryptophan 2,3-dioxygenase compensation

Indoleamine 2,3-dioxygenase 1 (IDO1) is an intracellular rate-limiting enzyme in the metabolism of tryptophan along the kynurenine pathway, subsequently mediating the immune response; however, the role of IDO1 in liver fibrosis and cirrhosis is still unclear. In this study, we investigated the role...

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Detalles Bibliográficos
Autores principales: Zhong, Weichao, Gao, Lei, Zhou, Zhenting, Lin, Haiyan, Chen, Chun, Huang, Peng, Huang, Weiliang, Zhou, Chuying, Huang, Shaohui, Nie, Linghui, Liu, Ye, Chen, Youming, Zhou, Daqiao, Lv, Zhiping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522192/
https://www.ncbi.nlm.nih.gov/pubmed/28465467
http://dx.doi.org/10.18632/oncotarget.17119

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