The G-protein coupled receptor 56, expressed in colonic stem and cancer cells, binds progastrin to promote proliferation and carcinogenesis

Overexpression of human progastrin increases colonic mucosal proliferation and colorectal cancer progression in mice. The G-protein coupled receptor 56 (GPR56) is known to regulate cell adhesion, migration, proliferation and stem cell biology, but its expression in the gut has not been studied. We h...

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Detalles Bibliográficos
Autores principales: Jin, Guangchun, Sakitani, Kosuke, Wang, Hongshan, Jin, Ying, Dubeykovskiy, Alexander, Worthley, Daniel L., Tailor, Yagnesh, Wang, Timothy C.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522213/
https://www.ncbi.nlm.nih.gov/pubmed/28380450
http://dx.doi.org/10.18632/oncotarget.16506

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522213/
https://www.ncbi.nlm.nih.gov/pubmed/28380450
http://dx.doi.org/10.18632/oncotarget.16506

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