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Identification of molecular biomarkers for pancreatic cancer with mRMR shortest path method

The high mortality rate of pancreatic cancer makes it one of the most studied diseases among all cancer types. Many researches have been conducted to understand the mechanism underlying its emergence and pathogenesis of this disease. Here, by using minimum-redundancy-maximum-relevance (mRMR) method,...

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Detalles Bibliográficos
Autores principales: Shen, Shuhua, Gui, Tuantuan, Ma, Chengcheng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522256/
https://www.ncbi.nlm.nih.gov/pubmed/28611293
http://dx.doi.org/10.18632/oncotarget.18186
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author Shen, Shuhua
Gui, Tuantuan
Ma, Chengcheng
author_facet Shen, Shuhua
Gui, Tuantuan
Ma, Chengcheng
author_sort Shen, Shuhua
collection PubMed
description The high mortality rate of pancreatic cancer makes it one of the most studied diseases among all cancer types. Many researches have been conducted to understand the mechanism underlying its emergence and pathogenesis of this disease. Here, by using minimum-redundancy-maximum-relevance (mRMR) method, we studied a set of transcriptome data of pancreatic cancer. As we gradually added features to achieve the most accurate classification results of Jackknife, a gene set of 9 genes was identified. They were NHS, SCML2, LAMC2, S100P, COL17A1, AMIGO2, PTPRR, KPNA7 and KCNN4. Through STRING 2.0 protein-protein interactions (PPIs) analysis, 40 proteins were identified in the shortest paths between genes in the gene set, 30 of them passed the permutation test, which indicated they were hubs in the background network. Those genes in the protein-protein interaction network were enriched to 37 functional modules, such as: negative regulation of transcription from RNA polymerase II promoter, negative regulation of ERK1 and ERK2 cascade and BMP signaling pathway. Our study indicated new mechanism of pancreatic cancer, suggesting potential therapeutic targets for further study.
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spelling pubmed-55222562017-08-21 Identification of molecular biomarkers for pancreatic cancer with mRMR shortest path method Shen, Shuhua Gui, Tuantuan Ma, Chengcheng Oncotarget Research Paper The high mortality rate of pancreatic cancer makes it one of the most studied diseases among all cancer types. Many researches have been conducted to understand the mechanism underlying its emergence and pathogenesis of this disease. Here, by using minimum-redundancy-maximum-relevance (mRMR) method, we studied a set of transcriptome data of pancreatic cancer. As we gradually added features to achieve the most accurate classification results of Jackknife, a gene set of 9 genes was identified. They were NHS, SCML2, LAMC2, S100P, COL17A1, AMIGO2, PTPRR, KPNA7 and KCNN4. Through STRING 2.0 protein-protein interactions (PPIs) analysis, 40 proteins were identified in the shortest paths between genes in the gene set, 30 of them passed the permutation test, which indicated they were hubs in the background network. Those genes in the protein-protein interaction network were enriched to 37 functional modules, such as: negative regulation of transcription from RNA polymerase II promoter, negative regulation of ERK1 and ERK2 cascade and BMP signaling pathway. Our study indicated new mechanism of pancreatic cancer, suggesting potential therapeutic targets for further study. Impact Journals LLC 2017-05-25 /pmc/articles/PMC5522256/ /pubmed/28611293 http://dx.doi.org/10.18632/oncotarget.18186 Text en Copyright: © 2017 Shen et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Shen, Shuhua
Gui, Tuantuan
Ma, Chengcheng
Identification of molecular biomarkers for pancreatic cancer with mRMR shortest path method
title Identification of molecular biomarkers for pancreatic cancer with mRMR shortest path method
title_full Identification of molecular biomarkers for pancreatic cancer with mRMR shortest path method
title_fullStr Identification of molecular biomarkers for pancreatic cancer with mRMR shortest path method
title_full_unstemmed Identification of molecular biomarkers for pancreatic cancer with mRMR shortest path method
title_short Identification of molecular biomarkers for pancreatic cancer with mRMR shortest path method
title_sort identification of molecular biomarkers for pancreatic cancer with mrmr shortest path method
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522256/
https://www.ncbi.nlm.nih.gov/pubmed/28611293
http://dx.doi.org/10.18632/oncotarget.18186
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