Combined use of irinotecan with histone deacetylase inhibitor belinostat could cause severe toxicity by inhibiting SN-38 glucuronidation via UGT1A1

SN-38, the active metabolite of irinotecan, and histone deacetylase inhibitors (HDACis) such as belinostat, vorinostat and panobinostat, have all been shown to be deactivated by glucuronidation via UGTs. Since they all compete for UGTs for deactivation, we aimed to investigate the inhibitory effect...

Descripción completa

Detalles Bibliográficos
Autores principales: Wang, Lingzhi, Linus Chan, Chong En, Wong, Andrea Li-Ann, Wong, Fang Cheng, Lim, Siew Woon, Chinnathambi, Arunachalam, Alharbi, Sulaiman Ali, Lee, Lawrence Soon-U, Soo, Ross, Yong, Wei Peng, Lee, Soo Chin, Ho, Paul Chi-Lui, Sethi, Gautam, Goh, Boon Cher
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Clinical Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522258/
https://www.ncbi.nlm.nih.gov/pubmed/28157715
http://dx.doi.org/10.18632/oncotarget.15017

Ejemplares similares

Ejemplares similares