Inhibiting translesion DNA synthesis as an approach to combat drug resistance to DNA damaging agents

Anti-cancer agents exert therapeutic effects by damaging DNA. Unfortunately, DNA polymerases can effectively replicate the formed DNA lesions to cause drug resistance and create more aggressive cancers. To understand this process at the cellular level, we developed an artificial nucleoside that visu...

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Detalles Bibliográficos
Autores principales: Choi, Jung-Suk, Kim, Seol, Motea, Edward, Berdis, Anthony
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522278/
https://www.ncbi.nlm.nih.gov/pubmed/28489578
http://dx.doi.org/10.18632/oncotarget.17254

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522278/
https://www.ncbi.nlm.nih.gov/pubmed/28489578
http://dx.doi.org/10.18632/oncotarget.17254

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