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Inhibiting translesion DNA synthesis as an approach to combat drug resistance to DNA damaging agents
Anti-cancer agents exert therapeutic effects by damaging DNA. Unfortunately, DNA polymerases can effectively replicate the formed DNA lesions to cause drug resistance and create more aggressive cancers. To understand this process at the cellular level, we developed an artificial nucleoside that visu...
| Autores principales: | , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Impact Journals LLC
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522278/ https://www.ncbi.nlm.nih.gov/pubmed/28489578 http://dx.doi.org/10.18632/oncotarget.17254 |