SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population

A genome-wide association study identified a common genetic variant rs4939827 at 18q21 in SMAD7 to be related with colorectal cancer (CRC) risk with OR=1.2 and P =7.80E-28. Until recently, several meta-analysis studies have been conducted, and reported significant association between rs4939827 and C...

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Autores principales: Zhang, Chunze, Li, Xichuan, Fu, Wenzheng, Wang, Yijia, Wang, Tao, Wang, Wenhong, Chen, Shuo, Qin, Hai, Zhang, Xipeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522279/
https://www.ncbi.nlm.nih.gov/pubmed/28467803
http://dx.doi.org/10.18632/oncotarget.17065
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author Zhang, Chunze
Li, Xichuan
Fu, Wenzheng
Wang, Yijia
Wang, Tao
Wang, Wenhong
Chen, Shuo
Qin, Hai
Zhang, Xipeng
author_facet Zhang, Chunze
Li, Xichuan
Fu, Wenzheng
Wang, Yijia
Wang, Tao
Wang, Wenhong
Chen, Shuo
Qin, Hai
Zhang, Xipeng
author_sort Zhang, Chunze
collection PubMed
description A genome-wide association study identified a common genetic variant rs4939827 at 18q21 in SMAD7 to be related with colorectal cancer (CRC) risk with OR=1.2 and P =7.80E-28. Until recently, several meta-analysis studies have been conducted, and reported significant association between rs4939827 and CRC risk. However none of these studies evaluated the potential association between rs4939827 and CRC risk in Chinese population. In this study, we evaluated this association by a meta-analysis using 12077 samples including 5816 CRC cases and 6261 controls. In the end, we identified the T allele of rs4939827 to be significantly related with an increase CRC risk (P=2.22E-05, OR=1.14, 95% CI 1.07-1.21) in Chinese population.
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spelling pubmed-55222792017-08-21 SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population Zhang, Chunze Li, Xichuan Fu, Wenzheng Wang, Yijia Wang, Tao Wang, Wenhong Chen, Shuo Qin, Hai Zhang, Xipeng Oncotarget Research Paper A genome-wide association study identified a common genetic variant rs4939827 at 18q21 in SMAD7 to be related with colorectal cancer (CRC) risk with OR=1.2 and P =7.80E-28. Until recently, several meta-analysis studies have been conducted, and reported significant association between rs4939827 and CRC risk. However none of these studies evaluated the potential association between rs4939827 and CRC risk in Chinese population. In this study, we evaluated this association by a meta-analysis using 12077 samples including 5816 CRC cases and 6261 controls. In the end, we identified the T allele of rs4939827 to be significantly related with an increase CRC risk (P=2.22E-05, OR=1.14, 95% CI 1.07-1.21) in Chinese population. Impact Journals LLC 2017-04-12 /pmc/articles/PMC5522279/ /pubmed/28467803 http://dx.doi.org/10.18632/oncotarget.17065 Text en Copyright: © 2017 Zhang et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Zhang, Chunze
Li, Xichuan
Fu, Wenzheng
Wang, Yijia
Wang, Tao
Wang, Wenhong
Chen, Shuo
Qin, Hai
Zhang, Xipeng
SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population
title SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population
title_full SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population
title_fullStr SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population
title_full_unstemmed SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population
title_short SMAD7 rs4939827 variant contributes to colorectal cancer risk in Chinese population
title_sort smad7 rs4939827 variant contributes to colorectal cancer risk in chinese population
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522279/
https://www.ncbi.nlm.nih.gov/pubmed/28467803
http://dx.doi.org/10.18632/oncotarget.17065
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