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High glucose induces formation of tau hyperphosphorylation via Cav-1-mTOR pathway: A potential molecular mechanism for diabetes-induced cognitive dysfunction

The abnormally hyperphosphorylated tau is thought to be implicated in diabetes-associated cognitive deficits. The role of mammalian target of rapamycin (mTOR) / S6 kinase (S6K) signalling in the formation of tau hyperphosphorylation has been previously studied. Caveolin-1 (Cav-1), the essential stru...

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Detalles Bibliográficos
Autores principales:	Wu, Jing, Zhou, Shan-Lei, Pi, Lin-Hua, Shi, Xia-Jie, Ma, Ling-Ran, Chen, Zi, Qu, Min-Li, Li, Xin, Nie, Sheng-Dan, Liao, Duan-Fang, Pei, Jin-Jing, Wang, Shan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Impact Journals LLC 2017
Materias:	Research Paper
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522306/ https://www.ncbi.nlm.nih.gov/pubmed/28489581 http://dx.doi.org/10.18632/oncotarget.17257

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