Adapting AlphaLISA high throughput screen to discover a novel small-molecule inhibitor targeting protein arginine methyltransferase 5 in pancreatic and colorectal cancers

Pancreatic ductal adenocarcinoma (PDAC) and colorectal cancer (CRC) are notoriously challenging for treatment. Hyperactive nuclear factor κB (NF-κB) is a common culprit in both cancers. Previously, we discovered that protein arginine methyltransferase 5 (PRMT5) methylated and activated NF-κB. Here,...

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Detalles Bibliográficos
Autores principales: Prabhu, Lakshmi, Wei, Han, Chen, Lan, Demir, Özlem, Sandusky, George, Sun, Emily, Wang, John, Mo, Jessica, Zeng, Lifan, Fishel, Melissa, Safa, Ahmad, Amaro, Rommie, Korc, Murray, Zhang, Zhong-Yin, Lu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Priority Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522311/
https://www.ncbi.nlm.nih.gov/pubmed/28591716
http://dx.doi.org/10.18632/oncotarget.18102

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