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Elevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus

Emerging evidence suggests that two heparin-binding growth factor, midkine and pleiotrophin are implicated in the pathogenesis of autoimmune diseases including SLE. To investigate the plasma midkine and pleiotrophin levels in SLE patients, as well as their correlation with major clinical parameters...

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Autores principales: Wu, Guo-Cui, Yuan, Hui, Pan, Hai-Feng, Ye, Dong-Qing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522313/
https://www.ncbi.nlm.nih.gov/pubmed/27903979
http://dx.doi.org/10.18632/oncotarget.13658
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author Wu, Guo-Cui
Yuan, Hui
Pan, Hai-Feng
Ye, Dong-Qing
author_facet Wu, Guo-Cui
Yuan, Hui
Pan, Hai-Feng
Ye, Dong-Qing
author_sort Wu, Guo-Cui
collection PubMed
description Emerging evidence suggests that two heparin-binding growth factor, midkine and pleiotrophin are implicated in the pathogenesis of autoimmune diseases including SLE. To investigate the plasma midkine and pleiotrophin levels in SLE patients, as well as their correlation with major clinical parameters and interleukin-17 (IL-17) level in SLE, 83 SLE patients and 123 controls including 20 rheumatoid arthritis (RA) patients, 21 Sjögren's syndrome (SS) patients and 82 healthy controls (HCs) were recruited. Plasma midkine, pleiotrophin and IL-17 levels were detected by ELISA. Midkine and pleiotrophin levels were significantly higher in SLE, RA and SS patients compared with HCs (all P < 0.05). There were significantly lower midkine and pleiotrophin levels in SLE compared to SS (P < 0.05 and P < 0.01, respectively). No significant differences in midkine and pleiotrophin levels were found between SLE and RA (P = 0.240 and P = 0.074, respectively). Both plasma midkine and pleiotrophin levels were associated with rash and anti-SSA in SLE. In addition, both midkine and pleiotrophin levels were positively associated with IL-17 level in SLE (both P < 0.001). Area under curve (AUC) of the receiver operating characteristic (ROC) curve for midkine and pleiotrophin were 0.606 (0.527–0.681) and 0.605 (0.526–0.680) respectively. In conclusion, elevated plasma midkine and pleiotrophin levels and their associations with rash, anti-SSA and IL-17 in SLE patients suggest their involvement in this disease.
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spelling pubmed-55223132017-08-21 Elevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus Wu, Guo-Cui Yuan, Hui Pan, Hai-Feng Ye, Dong-Qing Oncotarget Research Paper Emerging evidence suggests that two heparin-binding growth factor, midkine and pleiotrophin are implicated in the pathogenesis of autoimmune diseases including SLE. To investigate the plasma midkine and pleiotrophin levels in SLE patients, as well as their correlation with major clinical parameters and interleukin-17 (IL-17) level in SLE, 83 SLE patients and 123 controls including 20 rheumatoid arthritis (RA) patients, 21 Sjögren's syndrome (SS) patients and 82 healthy controls (HCs) were recruited. Plasma midkine, pleiotrophin and IL-17 levels were detected by ELISA. Midkine and pleiotrophin levels were significantly higher in SLE, RA and SS patients compared with HCs (all P < 0.05). There were significantly lower midkine and pleiotrophin levels in SLE compared to SS (P < 0.05 and P < 0.01, respectively). No significant differences in midkine and pleiotrophin levels were found between SLE and RA (P = 0.240 and P = 0.074, respectively). Both plasma midkine and pleiotrophin levels were associated with rash and anti-SSA in SLE. In addition, both midkine and pleiotrophin levels were positively associated with IL-17 level in SLE (both P < 0.001). Area under curve (AUC) of the receiver operating characteristic (ROC) curve for midkine and pleiotrophin were 0.606 (0.527–0.681) and 0.605 (0.526–0.680) respectively. In conclusion, elevated plasma midkine and pleiotrophin levels and their associations with rash, anti-SSA and IL-17 in SLE patients suggest their involvement in this disease. Impact Journals LLC 2016-11-26 /pmc/articles/PMC5522313/ /pubmed/27903979 http://dx.doi.org/10.18632/oncotarget.13658 Text en Copyright: © 2017 Wu et al. http://creativecommons.org/licenses/by/3.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License 3.0 (http://creativecommons.org/licenses/by/3.0/) (CC BY 3.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Paper
Wu, Guo-Cui
Yuan, Hui
Pan, Hai-Feng
Ye, Dong-Qing
Elevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus
title Elevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus
title_full Elevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus
title_fullStr Elevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus
title_full_unstemmed Elevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus
title_short Elevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus
title_sort elevated plasma midkine and pleiotrophin levels in patients with systemic lupus erythematosus
topic Research Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522313/
https://www.ncbi.nlm.nih.gov/pubmed/27903979
http://dx.doi.org/10.18632/oncotarget.13658
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