A systematic review and meta-analysis of individual patient data on the impact of the BIM deletion polymorphism on treatment outcomes in epidermal growth factor receptor mutant lung cancer

BACKGROUND: A germline deletion in the BIM (BCL2L11) gene has been shown to impair the apoptotic response to tyrosine kinase inhibitors (TKIs) in vitro but its association with poor outcomes in TKI-treated non-small cell lung cancer (NSCLC) patients remains unclear. We conducted a systematic review...

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Detalles Bibliográficos
Autores principales: Soh, Sheila X., Siddiqui, Fahad J., Allen, John C., Kim, Go Woon, Lee, Jae Cheol, Yatabe, Yasushi, Soda, Manabu, Mano, Hiroyuki, Soo, Ross A., Chin, Tan-Min, Ebi, Hiromichi, Yano, Seiji, Matsuo, Keitaro, Niu, Xiaomin, Lu, Shun, Isobe, Kazutoshi, Lee, Jih-Hsiang, Yang, James C., Zhao, Mingchuan, Zhou, Caicun, Lee, June-Koo, Lee, Se-Hoon, Lee, Ji Yun, Ahn, Myung-Ju, Tan, Tira J., Tan, Daniel S., Tan, Eng-Huat, Ong, S. Tiong, Lim, Wan-Teck
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals LLC 2017
Materias:
Meta-Analysis
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522319/
https://www.ncbi.nlm.nih.gov/pubmed/28467813
http://dx.doi.org/10.18632/oncotarget.17102

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