BRD3 and BRD4 BET Bromodomain Proteins Differentially Regulate Skeletal Myogenesis

Myogenic differentiation proceeds through a highly coordinated cascade of gene activation that necessitates epigenomic changes in chromatin structure. Using a screen of small molecule epigenetic probes we identified three compounds which inhibited myogenic differentiation in C2C12 myoblasts; (+)-JQ1...

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Detalles Bibliográficos
Autores principales: Roberts, Thomas C., Etxaniz, Usue, Dall’Agnese, Alessandra, Wu, Shwu-Yuan, Chiang, Cheng-Ming, Brennan, Paul E., Wood, Matthew J. A., Puri, Pier Lorenzo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522382/
https://www.ncbi.nlm.nih.gov/pubmed/28733670
http://dx.doi.org/10.1038/s41598-017-06483-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522382/
https://www.ncbi.nlm.nih.gov/pubmed/28733670
http://dx.doi.org/10.1038/s41598-017-06483-7

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