Anti-tubercular Activity of Pyrazinamide is Independent of trans-Translation and RpsA

Pyrazinamide (PZA) is a first line anti-tubercular drug for which the mechanism of action remains unresolved. Recently, it was proposed that the active form of PZA, pyrazinoic acid (POA), disrupts the ribosome rescue process of trans-translation in Mycobacterium tuberculosis. This model suggested th...

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Detalles Bibliográficos
Autores principales: Dillon, Nicholas A., Peterson, Nicholas D., Feaga, Heather A., Keiler, Kenneth C., Baughn, Anthony D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522395/
https://www.ncbi.nlm.nih.gov/pubmed/28733601
http://dx.doi.org/10.1038/s41598-017-06415-5

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522395/
https://www.ncbi.nlm.nih.gov/pubmed/28733601
http://dx.doi.org/10.1038/s41598-017-06415-5

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