The N-terminal dimerization is required for TDP-43 splicing activity

TDP-43 is a nuclear factor that functions in promoting pre-mRNA splicing. Deletion of the N-terminal domain (NTD) and nuclear localization signal (NLS) (i.e., TDP-35) results in mislocalization to cytoplasm and formation of inclusions. However, how the NTD functions in TDP-43 activity and proteinopa...

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Detalles Bibliográficos
Autores principales: Jiang, Lei-Lei, Xue, Wei, Hong, Jun-Ye, Zhang, Jun-Ting, Li, Min-Jun, Yu, Shao-Ning, He, Jian-Hua, Hu, Hong-Yu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522446/
https://www.ncbi.nlm.nih.gov/pubmed/28733604
http://dx.doi.org/10.1038/s41598-017-06263-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522446/
https://www.ncbi.nlm.nih.gov/pubmed/28733604
http://dx.doi.org/10.1038/s41598-017-06263-3

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