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Unexpected and striking effect of heparin-free dialysis on cytokine release

Heparin (both unfractionated and low molecular weight) is not only a potent anticoagulant but also has many pleiotropic effects, some of which are mediated by cytokine release. We compared the effect of hemodialysis (HD) with enoxaparin as an anticoagulant and without systemic anticoagulation (hepar...

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Autores principales: Rydzewska-Rosolowska, Alicja, Gozdzikiewicz-Lapinska, Joanna, Borawski, Jacek, Koc-Zorawska, Ewa, Mysliwiec, Michal, Naumnik, Beata
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Netherlands 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522500/
https://www.ncbi.nlm.nih.gov/pubmed/28425077
http://dx.doi.org/10.1007/s11255-017-1589-8
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author Rydzewska-Rosolowska, Alicja
Gozdzikiewicz-Lapinska, Joanna
Borawski, Jacek
Koc-Zorawska, Ewa
Mysliwiec, Michal
Naumnik, Beata
author_facet Rydzewska-Rosolowska, Alicja
Gozdzikiewicz-Lapinska, Joanna
Borawski, Jacek
Koc-Zorawska, Ewa
Mysliwiec, Michal
Naumnik, Beata
author_sort Rydzewska-Rosolowska, Alicja
collection PubMed
description Heparin (both unfractionated and low molecular weight) is not only a potent anticoagulant but also has many pleiotropic effects, some of which are mediated by cytokine release. We compared the effect of hemodialysis (HD) with enoxaparin as an anticoagulant and without systemic anticoagulation (heparin-grafted membrane—Evodial) on the release of monocyte chemoattractant protein 1 (MCP-1), endostatin (ES) and activin A (Act-A). Nineteen stable HD patients were dialyzed with or without heparin, and plasma levels of MCP-1, ES and Act-A were measured after such a dialysis. During HD with Evodial, the intradialytic levels of all three cytokines were 2–3 folds lower. The between-anticoagulant differences were significant over time for all three cytokines: MCP-1 (P < 0.001), ES (P < 0.001) and Act-A (P < 0.001). This striking effect of heparin-free dialysis with Evodial membrane may be beneficial not only because it reduces the possibility of bleeding complications but also because it might reduce proinflammatory cytokine concentration and therefore contribute to the improvement in endothelial function. Further studies are needed to determine whether it has a positive effect on morbidity and mortality of maintenance HD patients.
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spelling pubmed-55225002017-08-07 Unexpected and striking effect of heparin-free dialysis on cytokine release Rydzewska-Rosolowska, Alicja Gozdzikiewicz-Lapinska, Joanna Borawski, Jacek Koc-Zorawska, Ewa Mysliwiec, Michal Naumnik, Beata Int Urol Nephrol Nephrology – Original Paper Heparin (both unfractionated and low molecular weight) is not only a potent anticoagulant but also has many pleiotropic effects, some of which are mediated by cytokine release. We compared the effect of hemodialysis (HD) with enoxaparin as an anticoagulant and without systemic anticoagulation (heparin-grafted membrane—Evodial) on the release of monocyte chemoattractant protein 1 (MCP-1), endostatin (ES) and activin A (Act-A). Nineteen stable HD patients were dialyzed with or without heparin, and plasma levels of MCP-1, ES and Act-A were measured after such a dialysis. During HD with Evodial, the intradialytic levels of all three cytokines were 2–3 folds lower. The between-anticoagulant differences were significant over time for all three cytokines: MCP-1 (P < 0.001), ES (P < 0.001) and Act-A (P < 0.001). This striking effect of heparin-free dialysis with Evodial membrane may be beneficial not only because it reduces the possibility of bleeding complications but also because it might reduce proinflammatory cytokine concentration and therefore contribute to the improvement in endothelial function. Further studies are needed to determine whether it has a positive effect on morbidity and mortality of maintenance HD patients. Springer Netherlands 2017-04-19 2017 /pmc/articles/PMC5522500/ /pubmed/28425077 http://dx.doi.org/10.1007/s11255-017-1589-8 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made.
spellingShingle Nephrology – Original Paper
Rydzewska-Rosolowska, Alicja
Gozdzikiewicz-Lapinska, Joanna
Borawski, Jacek
Koc-Zorawska, Ewa
Mysliwiec, Michal
Naumnik, Beata
Unexpected and striking effect of heparin-free dialysis on cytokine release
title Unexpected and striking effect of heparin-free dialysis on cytokine release
title_full Unexpected and striking effect of heparin-free dialysis on cytokine release
title_fullStr Unexpected and striking effect of heparin-free dialysis on cytokine release
title_full_unstemmed Unexpected and striking effect of heparin-free dialysis on cytokine release
title_short Unexpected and striking effect of heparin-free dialysis on cytokine release
title_sort unexpected and striking effect of heparin-free dialysis on cytokine release
topic Nephrology – Original Paper
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522500/
https://www.ncbi.nlm.nih.gov/pubmed/28425077
http://dx.doi.org/10.1007/s11255-017-1589-8
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