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Unexpected and striking effect of heparin-free dialysis on cytokine release
Heparin (both unfractionated and low molecular weight) is not only a potent anticoagulant but also has many pleiotropic effects, some of which are mediated by cytokine release. We compared the effect of hemodialysis (HD) with enoxaparin as an anticoagulant and without systemic anticoagulation (hepar...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Springer Netherlands
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522500/ https://www.ncbi.nlm.nih.gov/pubmed/28425077 http://dx.doi.org/10.1007/s11255-017-1589-8 |
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author | Rydzewska-Rosolowska, Alicja Gozdzikiewicz-Lapinska, Joanna Borawski, Jacek Koc-Zorawska, Ewa Mysliwiec, Michal Naumnik, Beata |
author_facet | Rydzewska-Rosolowska, Alicja Gozdzikiewicz-Lapinska, Joanna Borawski, Jacek Koc-Zorawska, Ewa Mysliwiec, Michal Naumnik, Beata |
author_sort | Rydzewska-Rosolowska, Alicja |
collection | PubMed |
description | Heparin (both unfractionated and low molecular weight) is not only a potent anticoagulant but also has many pleiotropic effects, some of which are mediated by cytokine release. We compared the effect of hemodialysis (HD) with enoxaparin as an anticoagulant and without systemic anticoagulation (heparin-grafted membrane—Evodial) on the release of monocyte chemoattractant protein 1 (MCP-1), endostatin (ES) and activin A (Act-A). Nineteen stable HD patients were dialyzed with or without heparin, and plasma levels of MCP-1, ES and Act-A were measured after such a dialysis. During HD with Evodial, the intradialytic levels of all three cytokines were 2–3 folds lower. The between-anticoagulant differences were significant over time for all three cytokines: MCP-1 (P < 0.001), ES (P < 0.001) and Act-A (P < 0.001). This striking effect of heparin-free dialysis with Evodial membrane may be beneficial not only because it reduces the possibility of bleeding complications but also because it might reduce proinflammatory cytokine concentration and therefore contribute to the improvement in endothelial function. Further studies are needed to determine whether it has a positive effect on morbidity and mortality of maintenance HD patients. |
format | Online Article Text |
id | pubmed-5522500 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Springer Netherlands |
record_format | MEDLINE/PubMed |
spelling | pubmed-55225002017-08-07 Unexpected and striking effect of heparin-free dialysis on cytokine release Rydzewska-Rosolowska, Alicja Gozdzikiewicz-Lapinska, Joanna Borawski, Jacek Koc-Zorawska, Ewa Mysliwiec, Michal Naumnik, Beata Int Urol Nephrol Nephrology – Original Paper Heparin (both unfractionated and low molecular weight) is not only a potent anticoagulant but also has many pleiotropic effects, some of which are mediated by cytokine release. We compared the effect of hemodialysis (HD) with enoxaparin as an anticoagulant and without systemic anticoagulation (heparin-grafted membrane—Evodial) on the release of monocyte chemoattractant protein 1 (MCP-1), endostatin (ES) and activin A (Act-A). Nineteen stable HD patients were dialyzed with or without heparin, and plasma levels of MCP-1, ES and Act-A were measured after such a dialysis. During HD with Evodial, the intradialytic levels of all three cytokines were 2–3 folds lower. The between-anticoagulant differences were significant over time for all three cytokines: MCP-1 (P < 0.001), ES (P < 0.001) and Act-A (P < 0.001). This striking effect of heparin-free dialysis with Evodial membrane may be beneficial not only because it reduces the possibility of bleeding complications but also because it might reduce proinflammatory cytokine concentration and therefore contribute to the improvement in endothelial function. Further studies are needed to determine whether it has a positive effect on morbidity and mortality of maintenance HD patients. Springer Netherlands 2017-04-19 2017 /pmc/articles/PMC5522500/ /pubmed/28425077 http://dx.doi.org/10.1007/s11255-017-1589-8 Text en © The Author(s) 2017 Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. |
spellingShingle | Nephrology – Original Paper Rydzewska-Rosolowska, Alicja Gozdzikiewicz-Lapinska, Joanna Borawski, Jacek Koc-Zorawska, Ewa Mysliwiec, Michal Naumnik, Beata Unexpected and striking effect of heparin-free dialysis on cytokine release |
title | Unexpected and striking effect of heparin-free dialysis on cytokine release |
title_full | Unexpected and striking effect of heparin-free dialysis on cytokine release |
title_fullStr | Unexpected and striking effect of heparin-free dialysis on cytokine release |
title_full_unstemmed | Unexpected and striking effect of heparin-free dialysis on cytokine release |
title_short | Unexpected and striking effect of heparin-free dialysis on cytokine release |
title_sort | unexpected and striking effect of heparin-free dialysis on cytokine release |
topic | Nephrology – Original Paper |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522500/ https://www.ncbi.nlm.nih.gov/pubmed/28425077 http://dx.doi.org/10.1007/s11255-017-1589-8 |
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