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Frequent capsule switching in ‘ultra-virulent’ meningococci – Are we ready for a serogroup B ST-11 complex outbreak?
The meningococcal ST-11 complex (cc11) causes large invasive disease outbreaks with high case fatality rates, such as serogroup C (MenC) epidemics in industrialised nations in the 1990s and the serogroup W epidemic currently expanding globally. Glycoconjugate vaccines are available for serogroups A,...
Autores principales: | , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
W.B. Saunders
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522521/ https://www.ncbi.nlm.nih.gov/pubmed/28579305 http://dx.doi.org/10.1016/j.jinf.2017.05.015 |
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author | Lucidarme, Jay Lekshmi, Aiswarya Parikh, Sydel R. Bray, James E. Hill, Dorothea M. Bratcher, Holly B. Gray, Steve J. Carr, Anthony D. Jolley, Keith A. Findlow, Jamie Campbell, Helen Ladhani, Shamez N. Ramsay, Mary E. Maiden, Martin C.J. Borrow, Ray |
author_facet | Lucidarme, Jay Lekshmi, Aiswarya Parikh, Sydel R. Bray, James E. Hill, Dorothea M. Bratcher, Holly B. Gray, Steve J. Carr, Anthony D. Jolley, Keith A. Findlow, Jamie Campbell, Helen Ladhani, Shamez N. Ramsay, Mary E. Maiden, Martin C.J. Borrow, Ray |
author_sort | Lucidarme, Jay |
collection | PubMed |
description | The meningococcal ST-11 complex (cc11) causes large invasive disease outbreaks with high case fatality rates, such as serogroup C (MenC) epidemics in industrialised nations in the 1990s and the serogroup W epidemic currently expanding globally. Glycoconjugate vaccines are available for serogroups A, C, W and Y. Broad coverage protein-based vaccines have recently been licensed against serogroup B meningococci (MenB), however, these do not afford universal MenB protection. Capsular switching from MenC to MenB among cc11 organisms is concerning because a large MenB cc11 (B:cc11) outbreak has the potential to cause significant morbidity and mortality. This study aimed to assess the potential for licensed and developmental non-capsular meningococcal vaccines to protect against B:cc11. The population structure and vaccine antigen distribution was determined for a panel of >800 geo-temporally diverse, predominantly MenC cc11 and B:cc11 genomes. The two licensed vaccines potentially protect against many but not all B:cc11 meningococci. Furthermore, strain coverage by these vaccines is often due to a single vaccine antigen and both vaccines are highly susceptible to vaccine escape owing to the apparent dispensability of key proteins used as vaccine antigens. cc11 strains with MenB and MenC capsules warrant special consideration when formulating future non-capsular meningococcal vaccines. |
format | Online Article Text |
id | pubmed-5522521 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | W.B. Saunders |
record_format | MEDLINE/PubMed |
spelling | pubmed-55225212017-08-01 Frequent capsule switching in ‘ultra-virulent’ meningococci – Are we ready for a serogroup B ST-11 complex outbreak? Lucidarme, Jay Lekshmi, Aiswarya Parikh, Sydel R. Bray, James E. Hill, Dorothea M. Bratcher, Holly B. Gray, Steve J. Carr, Anthony D. Jolley, Keith A. Findlow, Jamie Campbell, Helen Ladhani, Shamez N. Ramsay, Mary E. Maiden, Martin C.J. Borrow, Ray J Infect Article The meningococcal ST-11 complex (cc11) causes large invasive disease outbreaks with high case fatality rates, such as serogroup C (MenC) epidemics in industrialised nations in the 1990s and the serogroup W epidemic currently expanding globally. Glycoconjugate vaccines are available for serogroups A, C, W and Y. Broad coverage protein-based vaccines have recently been licensed against serogroup B meningococci (MenB), however, these do not afford universal MenB protection. Capsular switching from MenC to MenB among cc11 organisms is concerning because a large MenB cc11 (B:cc11) outbreak has the potential to cause significant morbidity and mortality. This study aimed to assess the potential for licensed and developmental non-capsular meningococcal vaccines to protect against B:cc11. The population structure and vaccine antigen distribution was determined for a panel of >800 geo-temporally diverse, predominantly MenC cc11 and B:cc11 genomes. The two licensed vaccines potentially protect against many but not all B:cc11 meningococci. Furthermore, strain coverage by these vaccines is often due to a single vaccine antigen and both vaccines are highly susceptible to vaccine escape owing to the apparent dispensability of key proteins used as vaccine antigens. cc11 strains with MenB and MenC capsules warrant special consideration when formulating future non-capsular meningococcal vaccines. W.B. Saunders 2017-08 /pmc/articles/PMC5522521/ /pubmed/28579305 http://dx.doi.org/10.1016/j.jinf.2017.05.015 Text en Crown Copyright © 2017 The British Infection Association. Published by Elsevier Ltd. All rights reserved. |
spellingShingle | Article Lucidarme, Jay Lekshmi, Aiswarya Parikh, Sydel R. Bray, James E. Hill, Dorothea M. Bratcher, Holly B. Gray, Steve J. Carr, Anthony D. Jolley, Keith A. Findlow, Jamie Campbell, Helen Ladhani, Shamez N. Ramsay, Mary E. Maiden, Martin C.J. Borrow, Ray Frequent capsule switching in ‘ultra-virulent’ meningococci – Are we ready for a serogroup B ST-11 complex outbreak? |
title | Frequent capsule switching in ‘ultra-virulent’ meningococci – Are we ready for a serogroup B ST-11 complex outbreak? |
title_full | Frequent capsule switching in ‘ultra-virulent’ meningococci – Are we ready for a serogroup B ST-11 complex outbreak? |
title_fullStr | Frequent capsule switching in ‘ultra-virulent’ meningococci – Are we ready for a serogroup B ST-11 complex outbreak? |
title_full_unstemmed | Frequent capsule switching in ‘ultra-virulent’ meningococci – Are we ready for a serogroup B ST-11 complex outbreak? |
title_short | Frequent capsule switching in ‘ultra-virulent’ meningococci – Are we ready for a serogroup B ST-11 complex outbreak? |
title_sort | frequent capsule switching in ‘ultra-virulent’ meningococci – are we ready for a serogroup b st-11 complex outbreak? |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522521/ https://www.ncbi.nlm.nih.gov/pubmed/28579305 http://dx.doi.org/10.1016/j.jinf.2017.05.015 |
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