Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib

SU6656, a Src kinase inhibitor, was reported to increase fat oxidation and reduce body weight in mice, with proposed mechanisms involving AMP-activated protein kinase (AMPK) activation via inhibition of phosphorylation of either LKB1 or AMPK by the Src kinase, Fyn. However, we report that AMPK activ...

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Detalles Bibliográficos
Autores principales: Ross, Fiona A., Hawley, Simon A., Auciello, F. Romana, Gowans, Graeme J., Atrih, Abdelmadjid, Lamont, Douglas J., Hardie, D. Grahame
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cell Press 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522529/
https://www.ncbi.nlm.nih.gov/pubmed/28625738
http://dx.doi.org/10.1016/j.chembiol.2017.05.021

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