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The impact of examined lymph node count on survival in squamous cell carcinoma and adenocarcinoma of the uterine cervix

INTRODUCTION: The prognostic impact of the number of examined lymph nodes (ELNs) in different histological subtypes of cervical cancer remains unclear. We aimed to assess the impact of the number of ELNs in stage IA2–IIA cervical cancer with different histological subtypes. METHODS: Data of patients...

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Autores principales: Zhou, Juan, Zhang, Wen-Wen, Wu, San-Gang, He, Zhen-Yu, Sun, Jia-Yuan, Wang, Yan, Chen, Qiong-Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522663/
https://www.ncbi.nlm.nih.gov/pubmed/28761376
http://dx.doi.org/10.2147/CMAR.S141335
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author Zhou, Juan
Zhang, Wen-Wen
Wu, San-Gang
He, Zhen-Yu
Sun, Jia-Yuan
Wang, Yan
Chen, Qiong-Hua
author_facet Zhou, Juan
Zhang, Wen-Wen
Wu, San-Gang
He, Zhen-Yu
Sun, Jia-Yuan
Wang, Yan
Chen, Qiong-Hua
author_sort Zhou, Juan
collection PubMed
description INTRODUCTION: The prognostic impact of the number of examined lymph nodes (ELNs) in different histological subtypes of cervical cancer remains unclear. We aimed to assess the impact of the number of ELNs in stage IA2–IIA cervical cancer with different histological subtypes. METHODS: Data of patients with stage IA2–IIA squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the uterine cervix between 1988 and 2013 were retrieved from the Surveillance, Epidemiology, and End Results program. Univariate and multivariate Cox regression analyses were performed to analyze the effect of number of ELNs on cause-specific survival (CSS) and overall survival (OS). RESULTS: The final data set identified 11,830 patients including 7,920 (66.9%) women with SCC and 3,910 (33.1%) with AC. The median number of ELNs was 19. The multivariate analysis indicated that the number of ELNs was an independent prognostic factor influencing CSS and OS, both as a continuous or a categorical variable. Patients with a higher number of ELNs had better survival outcomes. In SCC subtype, the number of ELNs was also the independent prognostic factor of CSS and OS in node-positive patients, but not in patients with node-negative disease. In AC patients, ELN count was not an independent predictor of CSS and OS regardless of lymph node status. CONCLUSION: The number of ELNs is an independent prognostic factor in patients with stage IA2–IIB cervical cancer. A higher number of ELNs is associated with better survival outcomes, especially in the node-positive SCC subtype.
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spelling pubmed-55226632017-07-31 The impact of examined lymph node count on survival in squamous cell carcinoma and adenocarcinoma of the uterine cervix Zhou, Juan Zhang, Wen-Wen Wu, San-Gang He, Zhen-Yu Sun, Jia-Yuan Wang, Yan Chen, Qiong-Hua Cancer Manag Res Original Research INTRODUCTION: The prognostic impact of the number of examined lymph nodes (ELNs) in different histological subtypes of cervical cancer remains unclear. We aimed to assess the impact of the number of ELNs in stage IA2–IIA cervical cancer with different histological subtypes. METHODS: Data of patients with stage IA2–IIA squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the uterine cervix between 1988 and 2013 were retrieved from the Surveillance, Epidemiology, and End Results program. Univariate and multivariate Cox regression analyses were performed to analyze the effect of number of ELNs on cause-specific survival (CSS) and overall survival (OS). RESULTS: The final data set identified 11,830 patients including 7,920 (66.9%) women with SCC and 3,910 (33.1%) with AC. The median number of ELNs was 19. The multivariate analysis indicated that the number of ELNs was an independent prognostic factor influencing CSS and OS, both as a continuous or a categorical variable. Patients with a higher number of ELNs had better survival outcomes. In SCC subtype, the number of ELNs was also the independent prognostic factor of CSS and OS in node-positive patients, but not in patients with node-negative disease. In AC patients, ELN count was not an independent predictor of CSS and OS regardless of lymph node status. CONCLUSION: The number of ELNs is an independent prognostic factor in patients with stage IA2–IIB cervical cancer. A higher number of ELNs is associated with better survival outcomes, especially in the node-positive SCC subtype. Dove Medical Press 2017-07-18 /pmc/articles/PMC5522663/ /pubmed/28761376 http://dx.doi.org/10.2147/CMAR.S141335 Text en © 2017 Zhou et al. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Zhou, Juan
Zhang, Wen-Wen
Wu, San-Gang
He, Zhen-Yu
Sun, Jia-Yuan
Wang, Yan
Chen, Qiong-Hua
The impact of examined lymph node count on survival in squamous cell carcinoma and adenocarcinoma of the uterine cervix
title The impact of examined lymph node count on survival in squamous cell carcinoma and adenocarcinoma of the uterine cervix
title_full The impact of examined lymph node count on survival in squamous cell carcinoma and adenocarcinoma of the uterine cervix
title_fullStr The impact of examined lymph node count on survival in squamous cell carcinoma and adenocarcinoma of the uterine cervix
title_full_unstemmed The impact of examined lymph node count on survival in squamous cell carcinoma and adenocarcinoma of the uterine cervix
title_short The impact of examined lymph node count on survival in squamous cell carcinoma and adenocarcinoma of the uterine cervix
title_sort impact of examined lymph node count on survival in squamous cell carcinoma and adenocarcinoma of the uterine cervix
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522663/
https://www.ncbi.nlm.nih.gov/pubmed/28761376
http://dx.doi.org/10.2147/CMAR.S141335
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