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The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand
OBJECTIVE: To evaluate the cost utility and the budget impact of adjuvant racecadotril for the treatment of acute diarrhea in children in Thailand. METHODS: A cost utility model has been adapted to the context of Thailand to evaluate racecadotril plus oral rehydration solution (R+ORS) versus oral re...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Dove Medical Press
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522664/ https://www.ncbi.nlm.nih.gov/pubmed/28761363 http://dx.doi.org/10.2147/CEOR.S140902 |
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author | Rautenberg, Tamlyn Anne Zerwes, Ute |
author_facet | Rautenberg, Tamlyn Anne Zerwes, Ute |
author_sort | Rautenberg, Tamlyn Anne |
collection | PubMed |
description | OBJECTIVE: To evaluate the cost utility and the budget impact of adjuvant racecadotril for the treatment of acute diarrhea in children in Thailand. METHODS: A cost utility model has been adapted to the context of Thailand to evaluate racecadotril plus oral rehydration solution (R+ORS) versus oral rehydration solution (ORS) alone for acute diarrhea in children <5 years old. The decision tree Excel model evaluates the costs and effects (quality-adjusted life years) over a 6-day time horizon from a public health care payer’s perspective in Thailand. Deterministic sensitivity analysis and budget impact analysis have been undertaken. RESULTS: According to the cost utility model, the intervention (R+ORS) is less costly and more effective than the comparator (ORS) for the base case with a dominant incremental cost-effectiveness ratio of −2,481,390฿ for the intervention. According to the budget impact analysis (assuming an increase of 5% market share for R+ORS over 5 years), the year-on-year reduction for diarrhea as a percentage of the total health care expenditure is −0.0027%, resulting in potential net cost savings of −35,632,482฿ over 5 years. CONCLUSION: Subject to the assumptions and limitations of the models, adjuvant racecadotril versus ORS alone is potentially cost-effective for children in Thailand and uptake could translate into savings for the Thailand public health care system. |
format | Online Article Text |
id | pubmed-5522664 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Dove Medical Press |
record_format | MEDLINE/PubMed |
spelling | pubmed-55226642017-07-31 The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand Rautenberg, Tamlyn Anne Zerwes, Ute Clinicoecon Outcomes Res Original Research OBJECTIVE: To evaluate the cost utility and the budget impact of adjuvant racecadotril for the treatment of acute diarrhea in children in Thailand. METHODS: A cost utility model has been adapted to the context of Thailand to evaluate racecadotril plus oral rehydration solution (R+ORS) versus oral rehydration solution (ORS) alone for acute diarrhea in children <5 years old. The decision tree Excel model evaluates the costs and effects (quality-adjusted life years) over a 6-day time horizon from a public health care payer’s perspective in Thailand. Deterministic sensitivity analysis and budget impact analysis have been undertaken. RESULTS: According to the cost utility model, the intervention (R+ORS) is less costly and more effective than the comparator (ORS) for the base case with a dominant incremental cost-effectiveness ratio of −2,481,390฿ for the intervention. According to the budget impact analysis (assuming an increase of 5% market share for R+ORS over 5 years), the year-on-year reduction for diarrhea as a percentage of the total health care expenditure is −0.0027%, resulting in potential net cost savings of −35,632,482฿ over 5 years. CONCLUSION: Subject to the assumptions and limitations of the models, adjuvant racecadotril versus ORS alone is potentially cost-effective for children in Thailand and uptake could translate into savings for the Thailand public health care system. Dove Medical Press 2017-07-17 /pmc/articles/PMC5522664/ /pubmed/28761363 http://dx.doi.org/10.2147/CEOR.S140902 Text en © 2017 Rautenberg and Zerwes. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed. |
spellingShingle | Original Research Rautenberg, Tamlyn Anne Zerwes, Ute The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand |
title | The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand |
title_full | The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand |
title_fullStr | The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand |
title_full_unstemmed | The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand |
title_short | The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand |
title_sort | cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in thailand |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522664/ https://www.ncbi.nlm.nih.gov/pubmed/28761363 http://dx.doi.org/10.2147/CEOR.S140902 |
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