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The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand

OBJECTIVE: To evaluate the cost utility and the budget impact of adjuvant racecadotril for the treatment of acute diarrhea in children in Thailand. METHODS: A cost utility model has been adapted to the context of Thailand to evaluate racecadotril plus oral rehydration solution (R+ORS) versus oral re...

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Autores principales: Rautenberg, Tamlyn Anne, Zerwes, Ute
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Dove Medical Press 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522664/
https://www.ncbi.nlm.nih.gov/pubmed/28761363
http://dx.doi.org/10.2147/CEOR.S140902
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author Rautenberg, Tamlyn Anne
Zerwes, Ute
author_facet Rautenberg, Tamlyn Anne
Zerwes, Ute
author_sort Rautenberg, Tamlyn Anne
collection PubMed
description OBJECTIVE: To evaluate the cost utility and the budget impact of adjuvant racecadotril for the treatment of acute diarrhea in children in Thailand. METHODS: A cost utility model has been adapted to the context of Thailand to evaluate racecadotril plus oral rehydration solution (R+ORS) versus oral rehydration solution (ORS) alone for acute diarrhea in children <5 years old. The decision tree Excel model evaluates the costs and effects (quality-adjusted life years) over a 6-day time horizon from a public health care payer’s perspective in Thailand. Deterministic sensitivity analysis and budget impact analysis have been undertaken. RESULTS: According to the cost utility model, the intervention (R+ORS) is less costly and more effective than the comparator (ORS) for the base case with a dominant incremental cost-effectiveness ratio of −2,481,390฿ for the intervention. According to the budget impact analysis (assuming an increase of 5% market share for R+ORS over 5 years), the year-on-year reduction for diarrhea as a percentage of the total health care expenditure is −0.0027%, resulting in potential net cost savings of −35,632,482฿ over 5 years. CONCLUSION: Subject to the assumptions and limitations of the models, adjuvant racecadotril versus ORS alone is potentially cost-effective for children in Thailand and uptake could translate into savings for the Thailand public health care system.
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spelling pubmed-55226642017-07-31 The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand Rautenberg, Tamlyn Anne Zerwes, Ute Clinicoecon Outcomes Res Original Research OBJECTIVE: To evaluate the cost utility and the budget impact of adjuvant racecadotril for the treatment of acute diarrhea in children in Thailand. METHODS: A cost utility model has been adapted to the context of Thailand to evaluate racecadotril plus oral rehydration solution (R+ORS) versus oral rehydration solution (ORS) alone for acute diarrhea in children <5 years old. The decision tree Excel model evaluates the costs and effects (quality-adjusted life years) over a 6-day time horizon from a public health care payer’s perspective in Thailand. Deterministic sensitivity analysis and budget impact analysis have been undertaken. RESULTS: According to the cost utility model, the intervention (R+ORS) is less costly and more effective than the comparator (ORS) for the base case with a dominant incremental cost-effectiveness ratio of −2,481,390฿ for the intervention. According to the budget impact analysis (assuming an increase of 5% market share for R+ORS over 5 years), the year-on-year reduction for diarrhea as a percentage of the total health care expenditure is −0.0027%, resulting in potential net cost savings of −35,632,482฿ over 5 years. CONCLUSION: Subject to the assumptions and limitations of the models, adjuvant racecadotril versus ORS alone is potentially cost-effective for children in Thailand and uptake could translate into savings for the Thailand public health care system. Dove Medical Press 2017-07-17 /pmc/articles/PMC5522664/ /pubmed/28761363 http://dx.doi.org/10.2147/CEOR.S140902 Text en © 2017 Rautenberg and Zerwes. This work is published and licensed by Dove Medical Press Limited The full terms of this license are available at https://www.dovepress.com/terms.php and incorporate the Creative Commons Attribution – Non Commercial (unported, v3.0) License (http://creativecommons.org/licenses/by-nc/3.0/). By accessing the work you hereby accept the Terms. Non-commercial uses of the work are permitted without any further permission from Dove Medical Press Limited, provided the work is properly attributed.
spellingShingle Original Research
Rautenberg, Tamlyn Anne
Zerwes, Ute
The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand
title The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand
title_full The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand
title_fullStr The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand
title_full_unstemmed The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand
title_short The cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in Thailand
title_sort cost utility and budget impact of adjuvant racecadotril for acute diarrhea in children in thailand
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522664/
https://www.ncbi.nlm.nih.gov/pubmed/28761363
http://dx.doi.org/10.2147/CEOR.S140902
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