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Amyloid β1-42 (Aβ1-42) Induces the CDK2-Mediated Phosphorylation of Tau through the Activation of the mTORC1 Signaling Pathway While Promoting Neuronal Cell Death

Alzheimer’s disease (AD) is a neurodegenerative disorder, characterized by cognitive impairment and memory loss. Amyloid β1-42 (Aβ) and hyper-phosphorylation of microtubule-associated protein tau have been considered as major histological features in AD. However, the mechanism of how Aβ induces the...

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Detalles Bibliográficos
Autores principales:	Lee, Ki Hoon, Lee, Sei-Jung, Lee, Hyun Jik, Choi, Gee Euhn, Jung, Young Hyun, Kim, Dah Ihm, Gabr, Amr Ahmed, Ryu, Jung Min, Han, Ho Jae
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Neuroscience
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522873/ https://www.ncbi.nlm.nih.gov/pubmed/28790888 http://dx.doi.org/10.3389/fnmol.2017.00229

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