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CD56 in the Immune System: More Than a Marker for Cytotoxicity?
Over the past years, the phenotypic and functional boundaries distinguishing the main cell subsets of the immune system have become increasingly blurred. In this respect, CD56 (also known as neural cell adhesion molecule) is a very good example. CD56 is the archetypal phenotypic marker of natural ki...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2017
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522883/ https://www.ncbi.nlm.nih.gov/pubmed/28791027 http://dx.doi.org/10.3389/fimmu.2017.00892 |
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author | Van Acker, Heleen H. Capsomidis, Anna Smits, Evelien L. Van Tendeloo, Viggo F. |
author_facet | Van Acker, Heleen H. Capsomidis, Anna Smits, Evelien L. Van Tendeloo, Viggo F. |
author_sort | Van Acker, Heleen H. |
collection | PubMed |
description | Over the past years, the phenotypic and functional boundaries distinguishing the main cell subsets of the immune system have become increasingly blurred. In this respect, CD56 (also known as neural cell adhesion molecule) is a very good example. CD56 is the archetypal phenotypic marker of natural killer cells but can actually be expressed by many more immune cells, including alpha beta T cells, gamma delta T cells, dendritic cells, and monocytes. Common to all these CD56-expressing cell types are strong immunostimulatory effector functions, including T helper 1 cytokine production and an efficient cytotoxic capacity. Interestingly, both numerical and functional deficiencies and phenotypic alterations of the CD56(+) immune cell fraction have been reported in patients with various infectious, autoimmune, or malignant diseases. In this review, we will discuss our current knowledge on the expression and function of CD56 in the hematopoietic system, both in health and disease. |
format | Online Article Text |
id | pubmed-5522883 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2017 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-55228832017-08-08 CD56 in the Immune System: More Than a Marker for Cytotoxicity? Van Acker, Heleen H. Capsomidis, Anna Smits, Evelien L. Van Tendeloo, Viggo F. Front Immunol Immunology Over the past years, the phenotypic and functional boundaries distinguishing the main cell subsets of the immune system have become increasingly blurred. In this respect, CD56 (also known as neural cell adhesion molecule) is a very good example. CD56 is the archetypal phenotypic marker of natural killer cells but can actually be expressed by many more immune cells, including alpha beta T cells, gamma delta T cells, dendritic cells, and monocytes. Common to all these CD56-expressing cell types are strong immunostimulatory effector functions, including T helper 1 cytokine production and an efficient cytotoxic capacity. Interestingly, both numerical and functional deficiencies and phenotypic alterations of the CD56(+) immune cell fraction have been reported in patients with various infectious, autoimmune, or malignant diseases. In this review, we will discuss our current knowledge on the expression and function of CD56 in the hematopoietic system, both in health and disease. Frontiers Media S.A. 2017-07-24 /pmc/articles/PMC5522883/ /pubmed/28791027 http://dx.doi.org/10.3389/fimmu.2017.00892 Text en Copyright © 2017 Van Acker, Capsomidis, Smits and Van Tendeloo. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Immunology Van Acker, Heleen H. Capsomidis, Anna Smits, Evelien L. Van Tendeloo, Viggo F. CD56 in the Immune System: More Than a Marker for Cytotoxicity? |
title | CD56 in the Immune System: More Than a Marker for Cytotoxicity? |
title_full | CD56 in the Immune System: More Than a Marker for Cytotoxicity? |
title_fullStr | CD56 in the Immune System: More Than a Marker for Cytotoxicity? |
title_full_unstemmed | CD56 in the Immune System: More Than a Marker for Cytotoxicity? |
title_short | CD56 in the Immune System: More Than a Marker for Cytotoxicity? |
title_sort | cd56 in the immune system: more than a marker for cytotoxicity? |
topic | Immunology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5522883/ https://www.ncbi.nlm.nih.gov/pubmed/28791027 http://dx.doi.org/10.3389/fimmu.2017.00892 |
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