Reconstitution of T Cell Proliferation under Arginine Limitation: Activated Human T Cells Take Up Citrulline via L-Type Amino Acid Transporter 1 and Use It to Regenerate Arginine after Induction of Argininosuccinate Synthase Expression

In the tumor microenvironment, arginine is metabolized by arginase-expressing myeloid cells. This arginine depletion profoundly inhibits T cell functions and is crucially involved in tumor-induced immunosuppression. Reconstitution of adaptive immune functions in the context of arginase-mediated tumo...

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Detalles Bibliográficos
Autores principales: Werner, Anke, Koschke, Miriam, Leuchtner, Nadine, Luckner-Minden, Claudia, Habermeier, Alice, Rupp, Johanna, Heinrich, Christin, Conradi, Roland, Closs, Ellen I., Munder, Markus
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523021/
https://www.ncbi.nlm.nih.gov/pubmed/28791021
http://dx.doi.org/10.3389/fimmu.2017.00864

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