Upregulation of CYP17A1 by Sp1-mediated DNA demethylation confers temozolomide resistance through DHEA-mediated protection in glioma

Steroidogenesis-mediated production of neurosteroids is important for brain homeostasis. Cytochrome P450 17A1 (CYP17A1), which converts pregnenolone to dehydroepiandrosterone (DHEA) in endocrine organs and the brain, is required for prostate cancer progression and acquired chemotherapeutic resistanc...

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Detalles Bibliográficos
Autores principales: Chuang, J-Y, Lo, W-L, Ko, C-Y, Chou, S-Y, Chen, R-M, Chang, K-Y, Hung, J-J, Su, W-C, Chang, W-C, Hsu, T-I
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group 2017
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523064/
https://www.ncbi.nlm.nih.gov/pubmed/28530704
http://dx.doi.org/10.1038/oncsis.2017.31

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