Bidirectional Mast Cell–Eosinophil Interactions in Inflammatory Disorders and Cancer

Human mast cells (MCs) and eosinophils were first described and named by Paul Ehrlich. These cells have distinct myeloid progenitors and differ morphologically, ultrastructurally, immunologically, biochemically, and pharmacologically. However, MCs and eosinophils play a pivotal role in several aller...

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Autores principales: Galdiero, Maria Rosaria, Varricchi, Gilda, Seaf, Mansour, Marone, Giancarlo, Levi-Schaffer, Francesca, Marone, Gianni
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523083/
https://www.ncbi.nlm.nih.gov/pubmed/28791287
http://dx.doi.org/10.3389/fmed.2017.00103
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author Galdiero, Maria Rosaria
Varricchi, Gilda
Seaf, Mansour
Marone, Giancarlo
Levi-Schaffer, Francesca
Marone, Gianni
author_facet Galdiero, Maria Rosaria
Varricchi, Gilda
Seaf, Mansour
Marone, Giancarlo
Levi-Schaffer, Francesca
Marone, Gianni
author_sort Galdiero, Maria Rosaria
collection PubMed
description Human mast cells (MCs) and eosinophils were first described and named by Paul Ehrlich. These cells have distinct myeloid progenitors and differ morphologically, ultrastructurally, immunologically, biochemically, and pharmacologically. However, MCs and eosinophils play a pivotal role in several allergic disorders. In addition, these cells are involved in autoimmune disorders, cardiovascular diseases, and cancer. MCs are distributed throughout all normal human tissues, whereas eosinophils are present only in gastrointestinal tract, secondary lymphoid tissues, and adipose tissue, thymus, mammary gland, and uterus. However, in allergic disorders, MCs and eosinophils can form the “allergic effector unit.” Moreover, in several tumors, MCs and eosinophils can be found in close proximity. Therefore, it is likely that MCs have the capacity to modulate eosinophil functions and vice versa. For example, interleukin 5, stem cell factor, histamine, platelet-activating factor (PAF), prostaglandin D(2) (PGD(2)), cysteinyl leukotrienes, and vascular endothelial growth factors (VEGFs), produced by activated MCs, can modulate eosinophil functions through the engagement of specific receptors. In contrast, eosinophil cationic proteins such as eosinophil cationic protein and major basic protein (MBP), nerve growth factor, and VEGFs released by activated eosinophils can modulate MC functions. These bidirectional interactions between MCs and eosinophils might be relevant not only in allergic diseases but also in several inflammatory and neoplastic disorders.
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spelling pubmed-55230832017-08-08 Bidirectional Mast Cell–Eosinophil Interactions in Inflammatory Disorders and Cancer Galdiero, Maria Rosaria Varricchi, Gilda Seaf, Mansour Marone, Giancarlo Levi-Schaffer, Francesca Marone, Gianni Front Med (Lausanne) Medicine Human mast cells (MCs) and eosinophils were first described and named by Paul Ehrlich. These cells have distinct myeloid progenitors and differ morphologically, ultrastructurally, immunologically, biochemically, and pharmacologically. However, MCs and eosinophils play a pivotal role in several allergic disorders. In addition, these cells are involved in autoimmune disorders, cardiovascular diseases, and cancer. MCs are distributed throughout all normal human tissues, whereas eosinophils are present only in gastrointestinal tract, secondary lymphoid tissues, and adipose tissue, thymus, mammary gland, and uterus. However, in allergic disorders, MCs and eosinophils can form the “allergic effector unit.” Moreover, in several tumors, MCs and eosinophils can be found in close proximity. Therefore, it is likely that MCs have the capacity to modulate eosinophil functions and vice versa. For example, interleukin 5, stem cell factor, histamine, platelet-activating factor (PAF), prostaglandin D(2) (PGD(2)), cysteinyl leukotrienes, and vascular endothelial growth factors (VEGFs), produced by activated MCs, can modulate eosinophil functions through the engagement of specific receptors. In contrast, eosinophil cationic proteins such as eosinophil cationic protein and major basic protein (MBP), nerve growth factor, and VEGFs released by activated eosinophils can modulate MC functions. These bidirectional interactions between MCs and eosinophils might be relevant not only in allergic diseases but also in several inflammatory and neoplastic disorders. Frontiers Media S.A. 2017-07-24 /pmc/articles/PMC5523083/ /pubmed/28791287 http://dx.doi.org/10.3389/fmed.2017.00103 Text en Copyright © 2017 Galdiero, Varricchi, Seaf, Marone, Levi-Schaffer and Marone. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Medicine
Galdiero, Maria Rosaria
Varricchi, Gilda
Seaf, Mansour
Marone, Giancarlo
Levi-Schaffer, Francesca
Marone, Gianni
Bidirectional Mast Cell–Eosinophil Interactions in Inflammatory Disorders and Cancer
title Bidirectional Mast Cell–Eosinophil Interactions in Inflammatory Disorders and Cancer
title_full Bidirectional Mast Cell–Eosinophil Interactions in Inflammatory Disorders and Cancer
title_fullStr Bidirectional Mast Cell–Eosinophil Interactions in Inflammatory Disorders and Cancer
title_full_unstemmed Bidirectional Mast Cell–Eosinophil Interactions in Inflammatory Disorders and Cancer
title_short Bidirectional Mast Cell–Eosinophil Interactions in Inflammatory Disorders and Cancer
title_sort bidirectional mast cell–eosinophil interactions in inflammatory disorders and cancer
topic Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523083/
https://www.ncbi.nlm.nih.gov/pubmed/28791287
http://dx.doi.org/10.3389/fmed.2017.00103
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