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P2X7 Receptor Induces Tumor Necrosis Factor-α Converting Enzyme Activation and Release to Boost TNF-α Production

Tumor necrosis factor (TNF)-α is a major pro-inflammatory cytokine produced in response to toll-like receptor stimulation. TNF-α release is controlled by the activity of TNF-α converting enzyme (TACE) that cut membrane-bound TNF-α to shed its ectodomain as a soluble cytokine. The purinergic receptor...

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Detalles Bibliográficos
Autores principales:	Barberà-Cremades, Maria, Gómez, Ana I., Baroja-Mazo, Alberto, Martínez-Alarcón, Laura, Martínez, Carlos M., de Torre-Minguela, Carlos, Pelegrín, Pablo
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2017
Materias:	Immunology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523084/ https://www.ncbi.nlm.nih.gov/pubmed/28791020 http://dx.doi.org/10.3389/fimmu.2017.00862

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