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Optimal sampling of MRI slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studies

BACKGROUND: MRI slices of 1.5 mm thickness have been used in both cross sectional and longitudinal studies of osteoarthritis, but is difficult to apply to large studies as most techniques used in measuring knee cartilage volumes require substantial post-image processing. The aim of this study was to...

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Autores principales: Zhai, Guangju, Ding, Changhai, Cicuttini, Flavia, Jones, Graeme
Formato: Texto
Lenguaje:English
Publicado: BioMed Central 2005
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC552310/
https://www.ncbi.nlm.nih.gov/pubmed/15720725
http://dx.doi.org/10.1186/1471-2474-6-10
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author Zhai, Guangju
Ding, Changhai
Cicuttini, Flavia
Jones, Graeme
author_facet Zhai, Guangju
Ding, Changhai
Cicuttini, Flavia
Jones, Graeme
author_sort Zhai, Guangju
collection PubMed
description BACKGROUND: MRI slices of 1.5 mm thickness have been used in both cross sectional and longitudinal studies of osteoarthritis, but is difficult to apply to large studies as most techniques used in measuring knee cartilage volumes require substantial post-image processing. The aim of this study was to determine the optimal sampling of 1.5 mm thick slices of MRI scans to estimate knee cartilage volume in males and females for cross-sectional and longitudinal studies. METHODS: A total of 150 subjects had a sagittal T1-weighted fat-suppressed MRI scan of the right knee at a partition thickness of 1.5 mm to determine their cartilage volume. Fifty subjects had both baseline and 2-year follow up MRI scans. Lateral, medial tibial and patellar cartilage volumes were calculated with different samples from 1.5 mm thick slices by extracting one in two, one in three, and one in four to compare to cartilage volume and its rate of change. Agreement was assessed by means of intraclass correlation coefficient (ICC) and Bland & Altman plots. RESULTS: Compared to the whole sample of 1.5 mm thick slices, measuring every second to fourth slice led to very little under or over estimation in cartilage volume and its annual change. At all sites and subgroups, measuring every second slice had less than 1% mean difference in cartilage volume and its annual rate of change with all ICCs ≥ 0.98. CONCLUSION: Sampling alternate 1.5 mm thick MRI slices is sufficient for knee cartilage volume measurement in cross-sectional and longitudinal epidemiological studies with little increase in measurement error. This approach will lead to a substantial decrease in post-scan processing time.
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spelling pubmed-5523102005-03-06 Optimal sampling of MRI slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studies Zhai, Guangju Ding, Changhai Cicuttini, Flavia Jones, Graeme BMC Musculoskelet Disord Research Article BACKGROUND: MRI slices of 1.5 mm thickness have been used in both cross sectional and longitudinal studies of osteoarthritis, but is difficult to apply to large studies as most techniques used in measuring knee cartilage volumes require substantial post-image processing. The aim of this study was to determine the optimal sampling of 1.5 mm thick slices of MRI scans to estimate knee cartilage volume in males and females for cross-sectional and longitudinal studies. METHODS: A total of 150 subjects had a sagittal T1-weighted fat-suppressed MRI scan of the right knee at a partition thickness of 1.5 mm to determine their cartilage volume. Fifty subjects had both baseline and 2-year follow up MRI scans. Lateral, medial tibial and patellar cartilage volumes were calculated with different samples from 1.5 mm thick slices by extracting one in two, one in three, and one in four to compare to cartilage volume and its rate of change. Agreement was assessed by means of intraclass correlation coefficient (ICC) and Bland & Altman plots. RESULTS: Compared to the whole sample of 1.5 mm thick slices, measuring every second to fourth slice led to very little under or over estimation in cartilage volume and its annual change. At all sites and subgroups, measuring every second slice had less than 1% mean difference in cartilage volume and its annual rate of change with all ICCs ≥ 0.98. CONCLUSION: Sampling alternate 1.5 mm thick MRI slices is sufficient for knee cartilage volume measurement in cross-sectional and longitudinal epidemiological studies with little increase in measurement error. This approach will lead to a substantial decrease in post-scan processing time. BioMed Central 2005-02-20 /pmc/articles/PMC552310/ /pubmed/15720725 http://dx.doi.org/10.1186/1471-2474-6-10 Text en Copyright © 2005 Zhai et al; licensee BioMed Central Ltd. http://creativecommons.org/licenses/by/2.0 This is an Open Access article distributed under the terms of the Creative Commons Attribution License ( (http://creativecommons.org/licenses/by/2.0) ), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Zhai, Guangju
Ding, Changhai
Cicuttini, Flavia
Jones, Graeme
Optimal sampling of MRI slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studies
title Optimal sampling of MRI slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studies
title_full Optimal sampling of MRI slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studies
title_fullStr Optimal sampling of MRI slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studies
title_full_unstemmed Optimal sampling of MRI slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studies
title_short Optimal sampling of MRI slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studies
title_sort optimal sampling of mri slices for the assessment of knee cartilage volume for cross-sectional and longitudinal studies
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC552310/
https://www.ncbi.nlm.nih.gov/pubmed/15720725
http://dx.doi.org/10.1186/1471-2474-6-10
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