TMEM39A and Human Diseases: A Brief Review

Transmembrane Protein 39A (TMEM39A) is a member of TMEM family. The understanding about this protein is still limited. The earlier studies indicated that TMEM39A was a key mediator of autoimmune disease. TMEM39A seems to be involved in systemic lupus erythematosus and multiple sclerosis in numerous...

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Detalles Bibliográficos
Autores principales: Tran, Quangdon, Park, Jisoo, Lee, Hyunji, Hong, Youngeun, Hong, Suntaek, Park, Sungjin, Park, Jongsun, Kim, Seon-Hwan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Society of Toxicology 2017
Materias:
Review Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523561/
https://www.ncbi.nlm.nih.gov/pubmed/28744351
http://dx.doi.org/10.5487/TR.2017.33.3.205
Descripción
Sumario:Transmembrane Protein 39A (TMEM39A) is a member of TMEM family. The understanding about this protein is still limited. The earlier studies indicated that TMEM39A was a key mediator of autoimmune disease. TMEM39A seems to be involved in systemic lupus erythematosus and multiple sclerosis in numerous of populations. All of these works stop at insufficient information by using gene functioning methods such as: Genome-wide association studies (GWASs) and/or follow-up study. It is the fact that the less understood of TMEM39A actually is the attraction to the scientist in near future. In this review the current knowledge about TMEM39A and its possible roles in cell biology, physiology and pathology will be described.

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