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Obesity prevalence and related risk of comorbidities among HIV+ patients attending a New England ambulatory centre

BACKGROUND: Human immunodeficiency virus infection and obesity are pro‐inflammatory conditions that, when occurring together, may pose a synergistic risk for diabetes and cardiovascular disease. PURPOSE: The aim of the current study was (i) to document the prevalence of obesity in HIV+ patients trea...

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Autores principales: Becofsky, Katie M., Wing, Edward J., Wing, Rena R., Richards, Kathryn E., Gillani, Fizza S.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2016
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523689/
https://www.ncbi.nlm.nih.gov/pubmed/28835853
http://dx.doi.org/10.1002/osp4.38
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author Becofsky, Katie M.
Wing, Edward J.
Wing, Rena R.
Richards, Kathryn E.
Gillani, Fizza S.
author_facet Becofsky, Katie M.
Wing, Edward J.
Wing, Rena R.
Richards, Kathryn E.
Gillani, Fizza S.
author_sort Becofsky, Katie M.
collection PubMed
description BACKGROUND: Human immunodeficiency virus infection and obesity are pro‐inflammatory conditions that, when occurring together, may pose a synergistic risk for diabetes and cardiovascular disease. PURPOSE: The aim of the current study was (i) to document the prevalence of obesity in HIV+ patients treated at the Miriam Hospital Immunology Center (Providence, RI) and (ii) to investigate the relationship between obesity and comorbidities. METHODS: The study population consisted of 1,489 HIV+ adults (70% men; average age 48 ± 11 years) treated between 01/01/2012 and 06/30/2014. Separate logistic regressions tested the associations between overweight and obesity and comorbid diagnoses (diabetes, hypertension and cardiovascular disease), as compared with normal weight. Covariates included age, gender and smoking status. RESULTS: Approximately 37% of patients were overweight (body mass index 25.0–29.9), and an additional 28% were obese (body mass index ≥30.0). Obesity was associated with higher odds of comorbid diabetes (OR = 3.26, CI = 1.98–5.39) and hypertension (OR = 2.11, CI = 1.49–2.98). There was no significant association between obesity and the presence of cardiovascular disease (OR = 1.12, CI = 0.66–1.90). Overweight was associated only with higher odds of comorbid diabetes (OR = 1.72; CI = 1.02–2.88). CONCLUSION: Our findings demonstrate a heightened risk of comorbidities in overweight and obese HIV+ patients. Future studies should investigate whether weight loss interventions for this population can reduce cardiovascular and metabolic risk factors as they do in other populations.
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spelling pubmed-55236892017-08-21 Obesity prevalence and related risk of comorbidities among HIV+ patients attending a New England ambulatory centre Becofsky, Katie M. Wing, Edward J. Wing, Rena R. Richards, Kathryn E. Gillani, Fizza S. Obes Sci Pract Original Articles BACKGROUND: Human immunodeficiency virus infection and obesity are pro‐inflammatory conditions that, when occurring together, may pose a synergistic risk for diabetes and cardiovascular disease. PURPOSE: The aim of the current study was (i) to document the prevalence of obesity in HIV+ patients treated at the Miriam Hospital Immunology Center (Providence, RI) and (ii) to investigate the relationship between obesity and comorbidities. METHODS: The study population consisted of 1,489 HIV+ adults (70% men; average age 48 ± 11 years) treated between 01/01/2012 and 06/30/2014. Separate logistic regressions tested the associations between overweight and obesity and comorbid diagnoses (diabetes, hypertension and cardiovascular disease), as compared with normal weight. Covariates included age, gender and smoking status. RESULTS: Approximately 37% of patients were overweight (body mass index 25.0–29.9), and an additional 28% were obese (body mass index ≥30.0). Obesity was associated with higher odds of comorbid diabetes (OR = 3.26, CI = 1.98–5.39) and hypertension (OR = 2.11, CI = 1.49–2.98). There was no significant association between obesity and the presence of cardiovascular disease (OR = 1.12, CI = 0.66–1.90). Overweight was associated only with higher odds of comorbid diabetes (OR = 1.72; CI = 1.02–2.88). CONCLUSION: Our findings demonstrate a heightened risk of comorbidities in overweight and obese HIV+ patients. Future studies should investigate whether weight loss interventions for this population can reduce cardiovascular and metabolic risk factors as they do in other populations. John Wiley and Sons Inc. 2016-05-31 /pmc/articles/PMC5523689/ /pubmed/28835853 http://dx.doi.org/10.1002/osp4.38 Text en © 2016 The Authors. Obesity Science & Practice published by John Wiley & Sons Ltd, World Obesity and The Obesity Society. This is an open access article under the terms of the Creative Commons Attribution‐NonCommercial‐NoDerivs (http://creativecommons.org/licenses/by-nc-nd/4.0/) License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Articles
Becofsky, Katie M.
Wing, Edward J.
Wing, Rena R.
Richards, Kathryn E.
Gillani, Fizza S.
Obesity prevalence and related risk of comorbidities among HIV+ patients attending a New England ambulatory centre
title Obesity prevalence and related risk of comorbidities among HIV+ patients attending a New England ambulatory centre
title_full Obesity prevalence and related risk of comorbidities among HIV+ patients attending a New England ambulatory centre
title_fullStr Obesity prevalence and related risk of comorbidities among HIV+ patients attending a New England ambulatory centre
title_full_unstemmed Obesity prevalence and related risk of comorbidities among HIV+ patients attending a New England ambulatory centre
title_short Obesity prevalence and related risk of comorbidities among HIV+ patients attending a New England ambulatory centre
title_sort obesity prevalence and related risk of comorbidities among hiv+ patients attending a new england ambulatory centre
topic Original Articles
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523689/
https://www.ncbi.nlm.nih.gov/pubmed/28835853
http://dx.doi.org/10.1002/osp4.38
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