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Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai Study

BACKGROUND: Carotid‐femoral pulse‐wave velocity (cf‐PWV) and brachial‐ankle PWV (ba‐PWV) are the 2 most frequently applied PWV measurements. However, little is known about the comparison of hypertensive target organ damage (TOD) with cf‐PWV and ba‐PWV. METHODS AND RESULTS: A total of 1599 community‐...

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Autores principales: Lu, Yuyan, Zhu, Mengyun, Bai, Bin, Chi, Chen, Yu, Shikai, Teliewubai, Jiadela, Xu, Henry, Wang, Kai, Xiong, Jing, Zhou, Yiwu, Ji, Hongwei, Fan, Ximin, Yu, Xuejing, Li, Jue, Blacher, Jacques, Zhang, Yi, Xu, Yawei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523744/
https://www.ncbi.nlm.nih.gov/pubmed/28219916
http://dx.doi.org/10.1161/JAHA.116.004168
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author Lu, Yuyan
Zhu, Mengyun
Bai, Bin
Chi, Chen
Yu, Shikai
Teliewubai, Jiadela
Xu, Henry
Wang, Kai
Xiong, Jing
Zhou, Yiwu
Ji, Hongwei
Fan, Ximin
Yu, Xuejing
Li, Jue
Blacher, Jacques
Zhang, Yi
Xu, Yawei
author_facet Lu, Yuyan
Zhu, Mengyun
Bai, Bin
Chi, Chen
Yu, Shikai
Teliewubai, Jiadela
Xu, Henry
Wang, Kai
Xiong, Jing
Zhou, Yiwu
Ji, Hongwei
Fan, Ximin
Yu, Xuejing
Li, Jue
Blacher, Jacques
Zhang, Yi
Xu, Yawei
author_sort Lu, Yuyan
collection PubMed
description BACKGROUND: Carotid‐femoral pulse‐wave velocity (cf‐PWV) and brachial‐ankle PWV (ba‐PWV) are the 2 most frequently applied PWV measurements. However, little is known about the comparison of hypertensive target organ damage (TOD) with cf‐PWV and ba‐PWV. METHODS AND RESULTS: A total of 1599 community‐dwelling elderly subjects (age >65 years) in northern Shanghai were recruited from June 2014 to August 2015. Both cf‐PWV and ba‐PWV were measured using SphygmoCor and VP1000 systems, respectively. Within the framework of comprehensive cardiovascular examinations, risk factors were assessed, and asymptomatic TOD, including left ventricular mass index, peak transmitral pulsed Doppler velocity/early diastolic tissue Doppler velocity (E/Ea), carotid intima‐media thickness, arterial plaque, creatinine clearance rate, and urinary albumin‐creatinine ratio were all evaluated. Both PWVs were significantly associated with male sex, age, waist/hip circumference, fasting plasma glucose, and systolic blood pressure, and ba‐PWV was also significantly related to body mass index. Both PWVs were significantly correlated with most TOD. When cf‐PWV and ba‐PWV were both or separately put into the stepwise linear regression model together with cardiovascular risk factors and treatment, only cf‐PWV, but not ba‐PWV, was significantly associated with carotid intima‐media thickness and creatinine clearance rate (P<0.05). When cf‐PWV and ba‐PWV were both or separately put into the same full‐mode model after adjustment for confounders, only cf‐PWV, but not ba‐PWV, showed significant association with carotid intima‐media thickness and creatinine clearance rate (P<0.05). Similar results were observed in logistic regression analysis. CONCLUSIONS: Taken together, in the community‐dwelling elderly Chinese, cf‐PWV seems to be more closely associated with hypertensive TOD, especially vascular and renal TOD, as compared with ba‐PWV. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT02368938.
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spelling pubmed-55237442017-08-14 Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai Study Lu, Yuyan Zhu, Mengyun Bai, Bin Chi, Chen Yu, Shikai Teliewubai, Jiadela Xu, Henry Wang, Kai Xiong, Jing Zhou, Yiwu Ji, Hongwei Fan, Ximin Yu, Xuejing Li, Jue Blacher, Jacques Zhang, Yi Xu, Yawei J Am Heart Assoc Original Research BACKGROUND: Carotid‐femoral pulse‐wave velocity (cf‐PWV) and brachial‐ankle PWV (ba‐PWV) are the 2 most frequently applied PWV measurements. However, little is known about the comparison of hypertensive target organ damage (TOD) with cf‐PWV and ba‐PWV. METHODS AND RESULTS: A total of 1599 community‐dwelling elderly subjects (age >65 years) in northern Shanghai were recruited from June 2014 to August 2015. Both cf‐PWV and ba‐PWV were measured using SphygmoCor and VP1000 systems, respectively. Within the framework of comprehensive cardiovascular examinations, risk factors were assessed, and asymptomatic TOD, including left ventricular mass index, peak transmitral pulsed Doppler velocity/early diastolic tissue Doppler velocity (E/Ea), carotid intima‐media thickness, arterial plaque, creatinine clearance rate, and urinary albumin‐creatinine ratio were all evaluated. Both PWVs were significantly associated with male sex, age, waist/hip circumference, fasting plasma glucose, and systolic blood pressure, and ba‐PWV was also significantly related to body mass index. Both PWVs were significantly correlated with most TOD. When cf‐PWV and ba‐PWV were both or separately put into the stepwise linear regression model together with cardiovascular risk factors and treatment, only cf‐PWV, but not ba‐PWV, was significantly associated with carotid intima‐media thickness and creatinine clearance rate (P<0.05). When cf‐PWV and ba‐PWV were both or separately put into the same full‐mode model after adjustment for confounders, only cf‐PWV, but not ba‐PWV, showed significant association with carotid intima‐media thickness and creatinine clearance rate (P<0.05). Similar results were observed in logistic regression analysis. CONCLUSIONS: Taken together, in the community‐dwelling elderly Chinese, cf‐PWV seems to be more closely associated with hypertensive TOD, especially vascular and renal TOD, as compared with ba‐PWV. CLINICAL TRIAL REGISTRATION: URL: http://www.clinicaltrials.gov. Unique identifier: NCT02368938. John Wiley and Sons Inc. 2017-02-20 /pmc/articles/PMC5523744/ /pubmed/28219916 http://dx.doi.org/10.1161/JAHA.116.004168 Text en © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Lu, Yuyan
Zhu, Mengyun
Bai, Bin
Chi, Chen
Yu, Shikai
Teliewubai, Jiadela
Xu, Henry
Wang, Kai
Xiong, Jing
Zhou, Yiwu
Ji, Hongwei
Fan, Ximin
Yu, Xuejing
Li, Jue
Blacher, Jacques
Zhang, Yi
Xu, Yawei
Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai Study
title Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai Study
title_full Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai Study
title_fullStr Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai Study
title_full_unstemmed Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai Study
title_short Comparison of Carotid‐Femoral and Brachial‐Ankle Pulse‐Wave Velocity in Association With Target Organ Damage in the Community‐Dwelling Elderly Chinese: The Northern Shanghai Study
title_sort comparison of carotid‐femoral and brachial‐ankle pulse‐wave velocity in association with target organ damage in the community‐dwelling elderly chinese: the northern shanghai study
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5523744/
https://www.ncbi.nlm.nih.gov/pubmed/28219916
http://dx.doi.org/10.1161/JAHA.116.004168
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