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Sex Differences in Percutaneous Coronary Intervention—Insights From the Coronary Angiography and PCI Registry of the German Society of Cardiology

BACKGROUND: Several studies have suggested sex‐related differences in diagnostic and invasive therapeutic coronary procedures. METHODS AND RESULTS: Data from consecutive patients who were enrolled in the Coronary Angiography and PCI Registry of the German Society of Cardiology were analyzed. We aime...

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Autores principales: Heer, Tobias, Hochadel, Matthias, Schmidt, Karin, Mehilli, Julinda, Zahn, Ralf, Kuck, Karl‐Heinz, Hamm, Christian, Böhm, Michael, Ertl, Georg, Hoffmeister, Hans Martin, Sack, Stefan, Senges, Jochen, Massberg, Steffen, Gitt, Anselm K., Zeymer, Uwe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524024/
https://www.ncbi.nlm.nih.gov/pubmed/28320749
http://dx.doi.org/10.1161/JAHA.116.004972
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author Heer, Tobias
Hochadel, Matthias
Schmidt, Karin
Mehilli, Julinda
Zahn, Ralf
Kuck, Karl‐Heinz
Hamm, Christian
Böhm, Michael
Ertl, Georg
Hoffmeister, Hans Martin
Sack, Stefan
Senges, Jochen
Massberg, Steffen
Gitt, Anselm K.
Zeymer, Uwe
author_facet Heer, Tobias
Hochadel, Matthias
Schmidt, Karin
Mehilli, Julinda
Zahn, Ralf
Kuck, Karl‐Heinz
Hamm, Christian
Böhm, Michael
Ertl, Georg
Hoffmeister, Hans Martin
Sack, Stefan
Senges, Jochen
Massberg, Steffen
Gitt, Anselm K.
Zeymer, Uwe
author_sort Heer, Tobias
collection PubMed
description BACKGROUND: Several studies have suggested sex‐related differences in diagnostic and invasive therapeutic coronary procedures. METHODS AND RESULTS: Data from consecutive patients who were enrolled in the Coronary Angiography and PCI Registry of the German Society of Cardiology were analyzed. We aimed to compare sex‐related differences in in‐hospital outcomes of patients undergoing percutaneous coronary intervention (PCI) for stable coronary artery disease, non‐ST elevation acute coronary syndromes, ST elevation myocardial infarction, and cardiogenic shock. From 2007 until the end of 2009 data from 185 312 PCIs were prospectively registered: 27.9% of the PCIs were performed in women. Primary PCI success rate was identical between the sexes (94%). There were no sex‐related differences in hospital mortality among patients undergoing PCI for stable coronary artery disease, non‐ST elevation acute coronary syndromes, or cardiogenic shock except among ST elevation myocardial infarction patients. Compared to men, women undergoing primary PCI for ST elevation myocardial infarction have a higher risk of in‐hospital death, age‐adjusted odds ratio (1.19, 95% CI 1.06‐1.33), and risk of ischemic cardiac and cerebrovascular events (death, myocardial infarction, transient ischemic attack/stroke), (age‐adjusted odds ratio 1.19, 95% CI 1.16‐1.29). Furthermore, access‐related complications were twice as high in women, irrespective of the indication. CONCLUSIONS: Despite identical technical success rates of PCI between the 2 sexes, women with PCI for ST elevation myocardial infarction have a 20% higher age‐adjusted risk of death and of ischemic cardiac and cerebrovascular events. Further research is needed to determine the reasons for these differences.
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spelling pubmed-55240242017-08-15 Sex Differences in Percutaneous Coronary Intervention—Insights From the Coronary Angiography and PCI Registry of the German Society of Cardiology Heer, Tobias Hochadel, Matthias Schmidt, Karin Mehilli, Julinda Zahn, Ralf Kuck, Karl‐Heinz Hamm, Christian Böhm, Michael Ertl, Georg Hoffmeister, Hans Martin Sack, Stefan Senges, Jochen Massberg, Steffen Gitt, Anselm K. Zeymer, Uwe J Am Heart Assoc Original Research BACKGROUND: Several studies have suggested sex‐related differences in diagnostic and invasive therapeutic coronary procedures. METHODS AND RESULTS: Data from consecutive patients who were enrolled in the Coronary Angiography and PCI Registry of the German Society of Cardiology were analyzed. We aimed to compare sex‐related differences in in‐hospital outcomes of patients undergoing percutaneous coronary intervention (PCI) for stable coronary artery disease, non‐ST elevation acute coronary syndromes, ST elevation myocardial infarction, and cardiogenic shock. From 2007 until the end of 2009 data from 185 312 PCIs were prospectively registered: 27.9% of the PCIs were performed in women. Primary PCI success rate was identical between the sexes (94%). There were no sex‐related differences in hospital mortality among patients undergoing PCI for stable coronary artery disease, non‐ST elevation acute coronary syndromes, or cardiogenic shock except among ST elevation myocardial infarction patients. Compared to men, women undergoing primary PCI for ST elevation myocardial infarction have a higher risk of in‐hospital death, age‐adjusted odds ratio (1.19, 95% CI 1.06‐1.33), and risk of ischemic cardiac and cerebrovascular events (death, myocardial infarction, transient ischemic attack/stroke), (age‐adjusted odds ratio 1.19, 95% CI 1.16‐1.29). Furthermore, access‐related complications were twice as high in women, irrespective of the indication. CONCLUSIONS: Despite identical technical success rates of PCI between the 2 sexes, women with PCI for ST elevation myocardial infarction have a 20% higher age‐adjusted risk of death and of ischemic cardiac and cerebrovascular events. Further research is needed to determine the reasons for these differences. John Wiley and Sons Inc. 2017-03-20 /pmc/articles/PMC5524024/ /pubmed/28320749 http://dx.doi.org/10.1161/JAHA.116.004972 Text en © 2017 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley Blackwell. This is an open access article under the terms of the Creative Commons Attribution (http://creativecommons.org/licenses/by/4.0/) License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Research
Heer, Tobias
Hochadel, Matthias
Schmidt, Karin
Mehilli, Julinda
Zahn, Ralf
Kuck, Karl‐Heinz
Hamm, Christian
Böhm, Michael
Ertl, Georg
Hoffmeister, Hans Martin
Sack, Stefan
Senges, Jochen
Massberg, Steffen
Gitt, Anselm K.
Zeymer, Uwe
Sex Differences in Percutaneous Coronary Intervention—Insights From the Coronary Angiography and PCI Registry of the German Society of Cardiology
title Sex Differences in Percutaneous Coronary Intervention—Insights From the Coronary Angiography and PCI Registry of the German Society of Cardiology
title_full Sex Differences in Percutaneous Coronary Intervention—Insights From the Coronary Angiography and PCI Registry of the German Society of Cardiology
title_fullStr Sex Differences in Percutaneous Coronary Intervention—Insights From the Coronary Angiography and PCI Registry of the German Society of Cardiology
title_full_unstemmed Sex Differences in Percutaneous Coronary Intervention—Insights From the Coronary Angiography and PCI Registry of the German Society of Cardiology
title_short Sex Differences in Percutaneous Coronary Intervention—Insights From the Coronary Angiography and PCI Registry of the German Society of Cardiology
title_sort sex differences in percutaneous coronary intervention—insights from the coronary angiography and pci registry of the german society of cardiology
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524024/
https://www.ncbi.nlm.nih.gov/pubmed/28320749
http://dx.doi.org/10.1161/JAHA.116.004972
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