Identification of human IgG1 variant with enhanced FcRn binding and without increased binding to rheumatoid factor autoantibody

Various studies have demonstrated that Fc engineering to enhance neonatal Fc receptor (FcRn) binding is effective for elongating half-life or increasing cellular uptake of IgG. A previous study has shown that a N434H mutation to enhance FcRn binding resulted in increased binding to rheumatoid factor...

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Detalles Bibliográficos
Autores principales: Maeda, Atsuhiko, Iwayanagi, Yuki, Haraya, Kenta, Tachibana, Tatsuhiko, Nakamura, Genki, Nambu, Takeru, Esaki, Keiko, Hattori, Kunihiro, Igawa, Tomoyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2017
Materias:
Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524163/
https://www.ncbi.nlm.nih.gov/pubmed/28387635
http://dx.doi.org/10.1080/19420862.2017.1314873

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