Genetic identification of thiosulfate sulfurtransferase as an adipocyte-expressed anti-diabetic target in mice selected for leanness

Discovery of genetic mechanisms for resistance to obesity and diabetes may illuminate new therapeutic strategies for the treatment of this global health challenge. We used the polygenic Lean mouse model, selected for low adiposity over 60 generations, to identify thiosulfate sulfurtransferase (Tst,...

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Detalles Bibliográficos
Autores principales: Morton, Nicholas M., Beltram, Jasmina, Carter, Roderick N., Michailidou, Zoi, Gorjanc, Gregor, Fadden, Clare Mc, Barrios-Llerena, Martin E., Rodriguez-Cuenca, Sergio, Gibbins, Matthew T. G., Aird, Rhona E., Moreno-Navarrete, José Maria, Munger, Steven C., Svenson, Karen L., Gastaldello, Annalisa, Ramage, Lynne, Naredo, Gregorio, Zeyda, Maximilian, Wang, Zhao V., Howie, Alexander F., Saari, Aila, Sipilä, Petra, Stulnig, Thomas M., Gudnason, Vilmundur, Kenyon, Christopher J., Seckl, Jonathan R., Walker, Brian R., Webster, Scott P., Dunbar, Donald R., Churchill, Gary A., Vidal-Puig, Antonio, Fernandez-Real, José Manuel, Emilsson, Valur, Horvat, Simon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2016
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524189/
https://www.ncbi.nlm.nih.gov/pubmed/27270587
http://dx.doi.org/10.1038/nm.4115

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