Building bridges between cellular and molecular structural biology

The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The worksh...

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Detalles Bibliográficos
Autores principales: Patwardhan, Ardan, Brandt, Robert, Butcher, Sarah J, Collinson, Lucy, Gault, David, Grünewald, Kay, Hecksel, Corey, Huiskonen, Juha T, Iudin, Andrii, Jones, Martin L, Korir, Paul K, Koster, Abraham J, Lagerstedt, Ingvar, Lawson, Catherine L, Mastronarde, David, McCormick, Matthew, Parkinson, Helen, Rosenthal, Peter B, Saalfeld, Stephan, Saibil, Helen R, Sarntivijai, Sirarat, Solanes Valero, Irene, Subramaniam, Sriram, Swedlow, Jason R, Tudose, Ilinca, Winn, Martyn, Kleywegt, Gerard J
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2017
Materias:
Biophysics and Structural Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524535/
https://www.ncbi.nlm.nih.gov/pubmed/28682240
http://dx.doi.org/10.7554/eLife.25835
Descripción
Sumario:The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures. DOI: http://dx.doi.org/10.7554/eLife.25835.001

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