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Building bridges between cellular and molecular structural biology
The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The worksh...
| Autores principales: | , , , , , , , , , , , , , , , , , , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
eLife Sciences Publications, Ltd
2017
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524535/ https://www.ncbi.nlm.nih.gov/pubmed/28682240 http://dx.doi.org/10.7554/eLife.25835 |
| _version_ | 1783252479100583936 |
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| author | Patwardhan, Ardan Brandt, Robert Butcher, Sarah J Collinson, Lucy Gault, David Grünewald, Kay Hecksel, Corey Huiskonen, Juha T Iudin, Andrii Jones, Martin L Korir, Paul K Koster, Abraham J Lagerstedt, Ingvar Lawson, Catherine L Mastronarde, David McCormick, Matthew Parkinson, Helen Rosenthal, Peter B Saalfeld, Stephan Saibil, Helen R Sarntivijai, Sirarat Solanes Valero, Irene Subramaniam, Sriram Swedlow, Jason R Tudose, Ilinca Winn, Martyn Kleywegt, Gerard J |
| author_facet | Patwardhan, Ardan Brandt, Robert Butcher, Sarah J Collinson, Lucy Gault, David Grünewald, Kay Hecksel, Corey Huiskonen, Juha T Iudin, Andrii Jones, Martin L Korir, Paul K Koster, Abraham J Lagerstedt, Ingvar Lawson, Catherine L Mastronarde, David McCormick, Matthew Parkinson, Helen Rosenthal, Peter B Saalfeld, Stephan Saibil, Helen R Sarntivijai, Sirarat Solanes Valero, Irene Subramaniam, Sriram Swedlow, Jason R Tudose, Ilinca Winn, Martyn Kleywegt, Gerard J |
| author_sort | Patwardhan, Ardan |
| collection | PubMed |
| description | The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures. DOI: http://dx.doi.org/10.7554/eLife.25835.001 |
| format | Online Article Text |
| id | pubmed-5524535 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2017 |
| publisher | eLife Sciences Publications, Ltd |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-55245352017-07-26 Building bridges between cellular and molecular structural biology Patwardhan, Ardan Brandt, Robert Butcher, Sarah J Collinson, Lucy Gault, David Grünewald, Kay Hecksel, Corey Huiskonen, Juha T Iudin, Andrii Jones, Martin L Korir, Paul K Koster, Abraham J Lagerstedt, Ingvar Lawson, Catherine L Mastronarde, David McCormick, Matthew Parkinson, Helen Rosenthal, Peter B Saalfeld, Stephan Saibil, Helen R Sarntivijai, Sirarat Solanes Valero, Irene Subramaniam, Sriram Swedlow, Jason R Tudose, Ilinca Winn, Martyn Kleywegt, Gerard J eLife Biophysics and Structural Biology The integration of cellular and molecular structural data is key to understanding the function of macromolecular assemblies and complexes in their in vivo context. Here we report on the outcomes of a workshop that discussed how to integrate structural data from a range of public archives. The workshop identified two main priorities: the development of tools and file formats to support segmentation (that is, the decomposition of a three-dimensional volume into regions that can be associated with defined objects), and the development of tools to support the annotation of biological structures. DOI: http://dx.doi.org/10.7554/eLife.25835.001 eLife Sciences Publications, Ltd 2017-07-06 /pmc/articles/PMC5524535/ /pubmed/28682240 http://dx.doi.org/10.7554/eLife.25835 Text en http://creativecommons.org/publicdomain/zero/1.0/ This is an open-access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. The work is made available under the Creative Commons CC0 public domain dedication (http://creativecommons.org/publicdomain/zero/1.0/) . |
| spellingShingle | Biophysics and Structural Biology Patwardhan, Ardan Brandt, Robert Butcher, Sarah J Collinson, Lucy Gault, David Grünewald, Kay Hecksel, Corey Huiskonen, Juha T Iudin, Andrii Jones, Martin L Korir, Paul K Koster, Abraham J Lagerstedt, Ingvar Lawson, Catherine L Mastronarde, David McCormick, Matthew Parkinson, Helen Rosenthal, Peter B Saalfeld, Stephan Saibil, Helen R Sarntivijai, Sirarat Solanes Valero, Irene Subramaniam, Sriram Swedlow, Jason R Tudose, Ilinca Winn, Martyn Kleywegt, Gerard J Building bridges between cellular and molecular structural biology |
| title | Building bridges between cellular and molecular structural biology |
| title_full | Building bridges between cellular and molecular structural biology |
| title_fullStr | Building bridges between cellular and molecular structural biology |
| title_full_unstemmed | Building bridges between cellular and molecular structural biology |
| title_short | Building bridges between cellular and molecular structural biology |
| title_sort | building bridges between cellular and molecular structural biology |
| topic | Biophysics and Structural Biology |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524535/ https://www.ncbi.nlm.nih.gov/pubmed/28682240 http://dx.doi.org/10.7554/eLife.25835 |
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