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Life-threatening Bleed Secondary to Tumor Shrinkage Effectively Palliated with Radiotherapy

Inverted papilloma is a typically benign, but locally aggressive tumor arising from the nasal cavity and paranasal sinuses. Malignant transformation can occur in up to 10% of cases. Although spontaneous tumor bleeding can occur with malignancies, hemorrhage secondary to tumor shrinkage has not been...

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Detalles Bibliográficos
Autores principales: Tseng, Michelle, Yew, Wanyi, Jeyasekharan, Anand, Vellayappan, Balamurugan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Cureus 2017
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524565/
https://www.ncbi.nlm.nih.gov/pubmed/28775926
http://dx.doi.org/10.7759/cureus.1386
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author Tseng, Michelle
Yew, Wanyi
Jeyasekharan, Anand
Vellayappan, Balamurugan
author_facet Tseng, Michelle
Yew, Wanyi
Jeyasekharan, Anand
Vellayappan, Balamurugan
author_sort Tseng, Michelle
collection PubMed
description Inverted papilloma is a typically benign, but locally aggressive tumor arising from the nasal cavity and paranasal sinuses. Malignant transformation can occur in up to 10% of cases. Although spontaneous tumor bleeding can occur with malignancies, hemorrhage secondary to tumor shrinkage has not been reported. We present a patient with metastatic squamous cell carcinoma (from inverted papilloma) who developed a life-threatening bleed shortly after chemotherapy initiation. She was managed successfully with life-saving palliative radiotherapy (RT), delivered based on clinical markup. She was subsequently re-treated with highly conformal RT and chemotherapy to achieve a marked clinical response without surgery.
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spelling pubmed-55245652017-08-03 Life-threatening Bleed Secondary to Tumor Shrinkage Effectively Palliated with Radiotherapy Tseng, Michelle Yew, Wanyi Jeyasekharan, Anand Vellayappan, Balamurugan Cureus Oncology Inverted papilloma is a typically benign, but locally aggressive tumor arising from the nasal cavity and paranasal sinuses. Malignant transformation can occur in up to 10% of cases. Although spontaneous tumor bleeding can occur with malignancies, hemorrhage secondary to tumor shrinkage has not been reported. We present a patient with metastatic squamous cell carcinoma (from inverted papilloma) who developed a life-threatening bleed shortly after chemotherapy initiation. She was managed successfully with life-saving palliative radiotherapy (RT), delivered based on clinical markup. She was subsequently re-treated with highly conformal RT and chemotherapy to achieve a marked clinical response without surgery. Cureus 2017-06-24 /pmc/articles/PMC5524565/ /pubmed/28775926 http://dx.doi.org/10.7759/cureus.1386 Text en Copyright © 2017, Tseng et al. http://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Oncology
Tseng, Michelle
Yew, Wanyi
Jeyasekharan, Anand
Vellayappan, Balamurugan
Life-threatening Bleed Secondary to Tumor Shrinkage Effectively Palliated with Radiotherapy
title Life-threatening Bleed Secondary to Tumor Shrinkage Effectively Palliated with Radiotherapy
title_full Life-threatening Bleed Secondary to Tumor Shrinkage Effectively Palliated with Radiotherapy
title_fullStr Life-threatening Bleed Secondary to Tumor Shrinkage Effectively Palliated with Radiotherapy
title_full_unstemmed Life-threatening Bleed Secondary to Tumor Shrinkage Effectively Palliated with Radiotherapy
title_short Life-threatening Bleed Secondary to Tumor Shrinkage Effectively Palliated with Radiotherapy
title_sort life-threatening bleed secondary to tumor shrinkage effectively palliated with radiotherapy
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524565/
https://www.ncbi.nlm.nih.gov/pubmed/28775926
http://dx.doi.org/10.7759/cureus.1386
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AT vellayappanbalamurugan lifethreateningbleedsecondarytotumorshrinkageeffectivelypalliatedwithradiotherapy