Plakophilin-2 is required for transcription of genes that control calcium cycling and cardiac rhythm

Plakophilin-2 (PKP2) is a component of the desmosome and known for its role in cell–cell adhesion. Mutations in human PKP2 associate with a life-threatening arrhythmogenic cardiomyopathy, often of right ventricular predominance. Here, we use a range of state-of-the-art methods and a cardiomyocyte-sp...

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Detalles Bibliográficos
Autores principales: Cerrone, Marina, Montnach, Jerome, Lin, Xianming, Zhao, Yan-Ting, Zhang, Mingliang, Agullo-Pascual, Esperanza, Leo-Macias, Alejandra, Alvarado, Francisco J., Dolgalev, Igor, Karathanos, Thomas V., Malkani, Kabir, Van Opbergen, Chantal J.M., van Bavel, Joanne J.A., Yang, Hua-Qian, Vasquez, Carolina, Tester, David, Fowler, Steven, Liang, Fengxia, Rothenberg, Eli, Heguy, Adriana, Morley, Gregory E., Coetzee, William A., Trayanova, Natalia A., Ackerman, Michael J., van Veen, Toon A.B., Valdivia, Hector H., Delmar, Mario
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524637/
https://www.ncbi.nlm.nih.gov/pubmed/28740174
http://dx.doi.org/10.1038/s41467-017-00127-0

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