p62/SQSTM1/Sequestosome-1 is an N-recognin of the N-end rule pathway which modulates autophagosome biogenesis

Macroautophagy mediates the selective degradation of proteins and non-proteinaceous cellular constituents. Here, we show that the N-end rule pathway modulates macroautophagy. In this mechanism, the autophagic adapter p62/SQSTM1/Sequestosome-1 is an N-recognin that binds type-1 and type-2 N-terminal...

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Detalles Bibliográficos
Autores principales: Cha-Molstad, Hyunjoo, Yu, Ji Eun, Feng, Zhiwei, Lee, Su Hyun, Kim, Jung Gi, Yang, Peng, Han, Bitnara, Sung, Ki Woon, Yoo, Young Dong, Hwang, Joonsung, McGuire, Terry, Shim, Sang Mi, Song, Hyun Dong, Ganipisetti, Srinivasrao, Wang, Nuozhou, Jang, Jun Min, Lee, Min Jae, Kim, Seung Jun, Lee, Kyung Ho, Hong, Jin Tae, Ciechanover, Aaron, Mook-Jung, Inhee, Kim, Kwang Pyo, Xie, Xiang-Qun, Kwon, Yong Tae, Kim, Bo Yeon
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524641/
https://www.ncbi.nlm.nih.gov/pubmed/28740232
http://dx.doi.org/10.1038/s41467-017-00085-7

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