Evaluation of Sofosbuvir (β-D-2′-deoxy-2′-α-fluoro-2′-β-C-methyluridine) as an inhibitor of Dengue virus replication(#)

We evaluated Sofosbuvir (SOF), the anti-hepatitis C virus prodrug of β-d-2′-deoxy-2′-α-fluoro-2′-β-C-methyluridine-5′-monophosphate, for potential inhibitory activity against DENV replication. Both cell-based and biochemical assays, based on use of purified DENV full-length NS5 enzyme, were studied....

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Detalles Bibliográficos
Autores principales: Xu, Hong-Tao, Colby-Germinario, Susan P., Hassounah, Said A., Fogarty, Clare, Osman, Nathan, Palanisamy, Navaneethan, Han, Yingshan, Oliveira, Maureen, Quan, Yudong, Wainberg, Mark A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2017
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524696/
https://www.ncbi.nlm.nih.gov/pubmed/28740124
http://dx.doi.org/10.1038/s41598-017-06612-2

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