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Dopamine Burden Induced the Inactivation of Sonic Hedgehog Signaling to Cognitive Decline in Minimal Hepatic Encephalopathy

Minimal hepatic encephalopathy (MHE) is induced by elevated intracranial dopamine (DA). The relationship of the Shh pathway with memory loss in MHE, however, is elusive. In the current study, rats with MHE induced with DA displayed downregulation of the Shh pathway. Additionally, injection of Shh in...

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Detalles Bibliográficos
Autores principales:	Ding, Saidan, Yang, Jianjing, Huang, Xueli, Liu, Leping, Hu, Jiangnan, Xu, Zhu, Zhuge, Qichuan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	JKL International LLC 2017
Materias:	Original Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5524807/ https://www.ncbi.nlm.nih.gov/pubmed/28840059 http://dx.doi.org/10.14336/AD.2016.1123

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